雌激素对绝经后妇女原发性高血压患者胰岛素敏感性的影响

目的：探讨雌激素对绝经后妇女轻中度原发性高血压（EH）患胰岛素敏感性的影响。方法：35例绝经妇女轻中度EH患，每日口服倍美力（结合型雌激素）0．625mg，于服药前及服药后3个月末分别检测血压，空腹血糖（FBG），空腹血浆胰岛素（FINS），并作口服葡萄糖耐量试验，同时测定血浆胰岛素。结果：治疗后血压无明显变化（P＞0．05），而FBG，FINS水平明显降低（P＜0．01）。FINS敏感指数提高（P＜0．01），结论：雌激素可降低绝经后妇女轻中度EH患的血糖及FINS水平，显提高FINS敏感性。

The effects of estrogen on insulin sensitivity in postmenopausal women with mildand moderate essential hypertension

Objective: To study the effects of estrogen on insulin sensitivity in postmenopausal women with mild to moderate essential hypertension (EH).Methods:Thirty|five postmenopausal women with mild and moderate EH were given 0 625 mg Premarin(conjugated estrogen) daily, We examined blood pressure, the levels of plasma glucose and insulin in a fasting state at baseline and at the end of 3 months of therapy, The oral glucose tolerance test (OGTT) was performed, insulin was examined at the same time. Results: After treatment, blood pressure were changed no significantly, fasting plasma glucose and insulin levels significantly reduced ( P <0 01),insulin sensitivity indexes increased significantly( P <0 01). Conclusion: Estrogen may significantly reduce the levels of plasma glucose and insulin, increase insulin sensitivity in postmenopausal women with mild and moderate EH.