针刺对糖尿病周围神经病变治疗作用的实验研究

目的探讨针刺对糖尿病大鼠周围神经病变的机理.方法用链脲佐菌素造模.设立正常对照组、糖尿病模型组、降糖治疗组、针刺治疗组、药物治疗组.针刺治疗组取脾俞、肾俞、三阴交、足三里穴,隔日针刺1次.各组均于治疗4、8周测定大鼠热痛阈值、坐骨神经感觉神经传导速度(SNCV)、坐骨神经血流量并进行对照观察.结果治疗4周,与降糖治疗组比较,针刺治疗组热痛阈值降低,坐骨神经SNCV增加,坐骨神经血流量增加(P＜0.05).治疗8周,针刺治疗组和药物治疗组热痛阈值、坐骨神经SNCV与降糖治疗组差异显著(P＜0.05或P＜0.01),与正常对照组比较,差异无显著性.针刺治疗组坐骨神经血流量与降糖治疗组比较,差异显著(P＜0.05).结论益气养阴活血针刺治疗改善糖尿病大鼠坐骨神经功能的作用与弥可保相似,但针刺治疗起效迅速,而且能明显增加坐骨神经组织血流量.

Therapeutic effect of acupuncture on diabetic peripheral neuropathy

Objective To investigate the mechanism of acupuncture on diabetic peripheral neuropathy in rats. Method To establish to model with streptozotocin (STZ), and then the model was divided into the control group, diabetes group, glucose-lowering treatment group, acupuncture group and medicated group. In acupuncture group the acupoints of Pishu (BL20), Shenshu (BL23), Sanyinjiao (SP6) and Zusanli (ST36) were needled once every other day. The rat thermalgesia liminal value, sciatic neurosensory conduction velocity (SNCV) and blood flow were detected and compared in 4th and 8th week respectively in different groups. Results In 4th week the thermalgesia liminal value of acupuncture group decreased, SNCV and blood flow increased compared with that of glucose-lowering treatment group (P<0.05). In 8th week there was a significant difference between acupuncture group, medicated group and glucose-lowering treatment group in thermalgesia liminal value and SNCV (P<0.05 or P<0.01) without significant difference compared with the control group. There was a significant difference between acupuncture group and glucose-lowering treatment group in blood flow (P<0.05). Conclusion Acupuncture, with the effects of replenishing qi, nourishing yin and activating blood, has the similar effect with Methycobal on sciatic nerve of rats with diabetes, but the effect of acupuncture is more quick and obvious on the blood flow of sciatic nerve.