| 应激大鼠不同脑区Ca~（2＋）－ATPase和GSH－px活性的变化 |
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| 引用本文： | 陆任云,许燕,汪玉芳.应激大鼠不同脑区Ca~（2＋）－ATPase和GSH－px活性的变化[J].江苏大学学报(医学版),1996(4). |
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| 作者姓名： | 陆任云 许燕 汪玉芳 |
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| 摘 要： | 利用捆扎大鼠四肢固定头部后淹水制成应激模型，观察大鼠在应激时不同脑区Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性的改变。结果显示Ｃａ２＋－ＡＴＰａｓｅ和ＧＳＨ－ｐｘ活性都有显著增加，Ｃａ２＋－ＡＴＰａｓｅ活性增加高峰的出现在丘脑、下丘脑（１ｈ）先于大脑皮层和海马（２ｈ），而ＧＳＨ－ｐｘ活性的增加，大脑皮层与海马较之丘脑、下丘脑更为显著和持久。提示，在应激状态下，清除自由基的能力和清除细胞内Ｃａ２＋的能力都有所增加。
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| 关 键 词： | 大鼠，应激，大脑，Ca~（2＋）－ATPase，GSH－px |
Changes of Ca~(2 ) -ATPase and GSH-px Activity in Different Regions of Rat Brain Under Stress |
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| Lu Renyun.Changes of Ca~(2 ) -ATPase and GSH-px Activity in Different Regions of Rat Brain Under Stress[J].Journal of Jiangsu University Medicine Edition,1996(4). |
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| Authors: | Lu Renyun |
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| Institution: | Lu Renyun(Department of Biochemistry);Wang yufang(Department of Scientific Research);Xu yan(Department of Pathophoeiology) |
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| Abstract: | Using the stress model of bound and soaked rat,we observed the changes of Ca2 -ATPase and GSH-px activity in different regions of rat brain. The results showed that the activity of Ca12 -ATPase and GSH-px increased remarkably;the activity of Ca2 -ATPase increased in thalamus and hypothalamus(1h) before hippocampus and cerebral cort x(2h);the activity of GSH-px increased more remarkably and lastingly in hippocampus and cerebral cortex than in thalamns and hypothalamus. This indicates the action of free radical-clearing and calcium-clearing was enhanced in the rats under stress. |
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| Keywords: | Rat activity brain Ca~(2 )-ATPase GSH-px |
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