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| 肺部肿瘤致异位ACTH综合征7例报告并文献复习 | |
| 引用本文： | 张倩,窦京涛,谷伟军,杜锦,王先令,杨国庆,郭清华,杨丽娟,吕朝晖,巴建明,母义明,陆菊明,潘长玉. 肺部肿瘤致异位ACTH综合征7例报告并文献复习[J]. 山东医药, 2011, 51(16): 41-43 |
| 作者姓名： | 张倩 窦京涛 谷伟军 杜锦 王先令 杨国庆 郭清华 杨丽娟 吕朝晖 巴建明 母义明 陆菊明 潘长玉 |
| 作者单位： | 中国人民解放军总医院,北京,100853 |
| 基金项目： | 解放军总医院科技创新苗圃基金 |
| 摘 要： | 目的探讨肺部肿瘤致异位促肾上腺皮质激素（ACTH）综合征的临床特点。方法回顾性分析2000年11月～2009年12月解放军总医院内分泌科收治并确诊的7例肺部肿瘤致异位ACTH综合征患者的临床资料。结果高血压、糖尿病、低血钾、水肿为最常见的临床表现,多缺乏典型库欣综合征的体征;血ACTH和皮质醇、24 h尿游离皮质醇水平升高,皮质醇分泌均不被小剂量及大剂量地塞米松抑制试验所抑制;胸部薄层CT扫描能发现多数肺部病变;手术切除肺部病变、小细胞肺癌化疗效果较好;肾上腺切除为控制高皮质醇血症的有效手段。结论肺部肿瘤是导致异位ACTH综合征的常见病因,对于ACTH依赖性库欣综合征的患者应常规行胸部薄层CT来筛查肺部病变。 |
| 关 键 词： | 库欣综合征 肺肿瘤 ACTH综合征,异位 |
Ectopic ACTH syndrome caused by pulmonary neoplasm report of seven cases and review of literature |
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| ZHANG Qian,DOU Jing-tao,GU Wei-jun,DU Jin,WANG Xian-ling,YANG Guo-qing,GUO Qing-hua,YANG Li-juan,LV Zhao-hui,BA Jian-ming,MU Yi-ming,LU Ju-ming,PAN Chang-yu. Ectopic ACTH syndrome caused by pulmonary neoplasm report of seven cases and review of literature[J]. Shandong Medical Journal, 2011, 51(16): 41-43 | |
| Authors: | ZHANG Qian DOU Jing-tao GU Wei-jun DU Jin WANG Xian-ling YANG Guo-qing GUO Qing-hua YANG Li-juan LV Zhao-hui BA Jian-ming MU Yi-ming LU Ju-ming PAN Chang-yu |
| Affiliation: | ZHANG Qian,DOU Jing-tao,GU Wei-jun,DU Jin,WANG Xian-ling,YANG Guo-qing,GUO Qing-hua,YANG Li-juan,LV Zhao-hui,BA Jian-ming,MU Yi-ming,LU Ju-ming,PAN Chang-yu(The General Hospital of the People's Liberation Army,Beijing 100853,P.R.China) |
| Abstract: | Objective To analyze the clinical features of patients with ectopic ACTH syndrome caused by pulmonary neoplasm.Method Seven cases of ectopic ACTH syndrome caused by pulmonary neoplasm who were diagnosed in the General Hospital of the People's Liberation Army from 2000 to 2009 were analyzed retrospectively.Results Most patients admitted hospital because of hypertension,hyperglycemia,hypokalemia and edema,without overt presentation of Cushing syndrome.Laboratory findings included remarkable elevated plasma AC... |
| Keywords: | Cushing syndrome pulmonary neoplasms ACTH syndrome ectopic. |
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