| Neural stem cell markers, nestin and musashi proteins, in the progression of human glioma： correlation of nestin with prognosis of patient survival |
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| 作者姓名： | Strojnik T R？sland GV Sakariassen PO Kavalat R Lab T |
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| 作者单位： | Department of Neurosurgery, Maribor Teaching Hospital, SI-2000 Maribor, Slovenia. |
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| 摘 要： | ![]()
BACKGROUND： The IF protein nestin and the RNA-binding protein musashi are expressed by neural progenitor cells during CNS development. Their expression in glial tumors was evaluated by immunohistochemistry, and the histopathological scores correlated with levels of cysteine cathepsins that are known prognostic markers in several tumors. METHODS： The levels of nestin, musashi, and cathepsins B and L were assessed by immunohistochemical analysis of biopsies from 87 patients with primary CNS tumors. To confirm the immunohistochemical data, nestin expression was analyzed by real-time PCR in 12 brain tumor biopsies.[第一段]
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| 关 键 词： | 神经干细胞 神经胶质瘤 预后 生存率 相关分析 nestin |
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