| 前列腺癌的神经内分泌分化 |
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| 引用本文： | Jingwen Wang,Yang Yao.前列腺癌的神经内分泌分化[J].中德临床肿瘤学杂志,2008,7(3):150-153. |
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| 作者姓名： | Jingwen Wang Yang Yao |
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| 作者单位： | Jingwen Wang（Department of Oncology, Shanghai Sixth People's Hospital, Jiaotong University, Shanghai 200233, China）
Yang Yao（Department of Oncology, Shanghai Sixth People's Hospital, Jiaotong University, Shanghai 200233, China） |
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| 摘 要： |
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| 关 键 词： | prostate cancer neuroendocrine differentiation drug resistance 前列腺癌 神经 内分泌分化 prostate cancer differentiation mechanism neuroendocrine relationship paper prognosis manifold neural peptide hormones lead growth tumor cells metastatic therapy treatment |
| 收稿时间： | 27 November 2007 |
| 修稿时间： | 30 January 2008 |
Neuroendocrine differentiation in prostate cancer |
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| Jingwen Wang,Yang Yao.Neuroendocrine differentiation in prostate cancer[J].The Chinese-German Journal of Clinical Oncology,2008,7(3):150-153. |
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| Authors: | Jingwen Wang Yang Yao |
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| Institution: | (1) Department of Oncology, Shanghai Sixth People’s Hospital, Jiaotong University, Shanghai, 200233, China |
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| Abstract: | Hormonal therapy is an important treatment for advanced/metastatic prostate cancer. But it can induce neuroen-docrine (NE) differentiation in prostate cancer cells. These NE cells will secrete manifold neural peptide or hormones which can lead to androgen-independent growth of non-NE tumor cells. When this happens, hormonal therapy becomes useless and indicates bad prognosis. In this paper, the mechanism of neuroendocrine differentiation and its relationship with androgen-independent were reviewed. |
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| Keywords: | prostate cancer neuroendocrine differentiation drug resistance |
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