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| 糖尿病基因治疗的研究新进展 | |
| 引用本文： | 游硕,张清. 糖尿病基因治疗的研究新进展[J]. 国际病理科学与临床杂志, 2011, 31(1): 69-72. DOI: 10.3969/j.issn.1673-2588.2011.01.014 |
| 作者姓名： | 游硕 张清 |
| 作者单位： | 1. 中南大学,湘雅二医院内分泌科,长沙,410011;中南大学,代谢内分泌研究所,长沙,410011 2. 中南大学,湘雅二医院眼科,长沙,410011 |
| 摘 要： | 1型糖尿病和2型糖尿病在全球范围内的流行,严重危害人类健康,加重了各国医疗负担.随着基因治疗技术的迅速发展,为糖尿病的基因治疗带来了新的思路.本文总结了利用合适的启动子载送胰岛素原的cDNA,刺激新的β细胞生成以达到恢复胰岛素的生理性分泌及改善或避免破坏β细胞免疫应答的1型糖尿病基因治疗进展和以肠促胰岛素胰高血糖素样肽... |
| 关 键 词： | 糖尿病 基因治疗 研究进展 |
Research updates of diabetic gene therapy |
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| YOU Shuo,ZHANG Qing. Research updates of diabetic gene therapy[J]. Journal of International Pathology and Clinical Medicine, 2011, 31(1): 69-72. DOI: 10.3969/j.issn.1673-2588.2011.01.014 | |
| Authors: | YOU Shuo ZHANG Qing |
| Affiliation: | YOU Shuo1,2,ZHANG Qing3,ZHOU Zhiguang1,2(1.Department of Endocrinology,Second Xiangya Hospital,2.Institute of Metabolism and Endocrinology,3.Department of Ophthalmology,Central South University,Changsha 410011,China) |
| Abstract: | The worldwide prevalence of both Type 1 and Type 2 diabetes threatens people’s health and drives up healthcare cost.Scientists are now taking advantages of the rapidly developing technology of gene therapy to treat diabetes.This article summarized the advances in Type 1 diabetic gene therapy such as using suitable promoter expressing proinsulin cDNA to stimulate new β-cell formation and insulin secretion as well as to improve immunologic response or avoid immune destruction of β-cells.The advances in Type 2 diabetic gene therapy were mainly focused on glucagon like peptide-1 and angiotensin I converting enzyme 2.This review also made prediction on the future of diabetic gene therapy. |
| Keywords: | diabetes gene therapy research update |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |