Immunomodulating effects of α1-acid glycoprotein (Orosomucoid) in a culture of human peripheral blood lymphocytesglycoprotein (Orosomucoid) in a culture of human peripheral blood lymphocytes |
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| Authors: | A. L. Pukhal'skii A. P. Toptygina E. A. Kalashnikova S. D. Shiyan V. V. Nasonov N. V. Bovin A. G. Lyutov F. T. Bairushin |
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| Affiliation: | (1) Research Center for Medical Genetics, Russian Academy of Medical Sciences, Moscow;(2) Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow;(3) Immunopreparat Conglomerate, Ufa |
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| Abstract: | ![]()
The mechanisms of the antiproliferative effect of α1-acid glycoprotein (AGP) isolated from the blood of healthy donors (nAGP) and from the ascitic fluid of patients with stomach cancer (aAGP) are studied. Three fractions of AGP are divided into 3 groups according to their ability to bind to concanavalin A (ConA): AGP not binding to ConA (AGP-1) and AGP weakly (AGP-2) and strongly (AGP-3) binding to ConA. It is shown that native preparation of aAGP has a more potent inhibitory effect on lymphocyte proliferation than native preparation of nAGP. The most potent inhibitory effect is exerted by AGP-3. Native preparation of aAGP does not affect the secretion of interleukin-2 (IL-2) by lymphocytes, whereas AGP-1 inhibits this process. The weakly bound fraction has a stimulatory effect both on the proliferative response and on IL-2 secretion. Translated fromByulleten' Eksperimental'noi Biologii i Meditsiny, Vol. 118, N o 7, pp. 71–73, July, 1994 |
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| Keywords: | orosomycoid lymphocyte proliferation interleukin-2 production |
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