Arthritis Research UK/MRC Centre for Musculoskeletal Work and Health, Southampton General Hospital, Southampton, Hampshire, United Kingdom;3. Orthopedic surgery, Wakayama Medical University, Wakayama city, Wakayama prefecture, Japan;4. Faculty of Medicine, Department of Preventive Medicine for Locomotive Organ Disorders, 22nd Century Medical & Research Center, University of Tokyo, Tokyo, Japan;5. Department of Orthopedic Surgery, Sensory and Motor System Medicine, Graduate School of Medicine, University of Tokyo, Tokyo, Japan;6. Department of Joint Disease Research, 22nd Century Medical and Research Center, University of Tokyo, Tokyo, Japan