首页 | 本学科首页   官方微博 | 高级检索  
     


Effects of polychlormated biphenyls on dopamine release from PC 12 cells
Affiliation:1. Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, TX 78712, United States;2. Division of Pharmacology and Toxicology, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, United States;3. Section of Integrative Biology, The University of Texas at Austin, Austin, TX 78712, United States
Abstract:
In PC12 cells, Aroclor 1254 produced a concentration-dependent decrease in basal and K +-evoked dopamine (DA) release, and cellular DA levels. Aroclor 1254 did not alter the fraction of cellular DA released, suggesting that the decreased release of DA was solely due to decreased cellular levels of DA, and not to decreased packaging of DA or inhibition of neurotransmitter release. The coplanar congener 3,3′,4,4′,5-pentachlorobiphenyl decreased cellular DA levels and release of DA at levels that produced cytotoxicity. Absent of any apparent cytotoxicity, the ortho-substituted PCB congeners 2,2′,5,5′-tetrachlorobiphenyl, 2,2′,3,3′,4,4′-hexachlorobiphenyl, 2,3′,4,4′,5-pentachlorobiphenyl, and 2,2′,4,4′,5,5′-hexachlorobiphenyl were effective in decreasing the amount of DA released from PC12 cells. These results suggest that ortho-chlorinated PCBs can cause decreased K+-evoked DA release through non-Ah receptormediated mechanisms. Furthermore, the PCB-mediated decrease m DA release was not due to impairment of DA packaging or release, but only due to decreased cellular DA levels.
Keywords:
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号