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2-Phenylimidazo[1,2-a]pyridine-3-carboxylic Acid Derivatives: Synthesis and Antiinflammatory Activity |
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| Authors: | Anna Di Chiacchio Maria Grazia Rimoli Lucia Avallone Francesca Arena Enrico Abignente Walter Filippelli Amelia Filippelli Guiseppe Falcone |
| Abstract: | A series of 2-phenylimidazo[1,2-a]pyridine-3-carboxylic esters, acids, and amides were synthesized and pharmacologically tested in order to evaluate their antiinflammatory and analgesic activity and their ulcerogenic action on the gastro-intestinal tract. The most active member of this series of compounds was found to be 6-methyl-2-phenylimidazo[1,2-a]pyridine-3-carboxylic acid ( 5c ). |
| Keywords: | Imidazo[1,2-a]pyridines antiinflammatory activity analgesic activity ulcerogenic activity |