Evaluation of two commercialised in situ hybridisation assays for detecting HPV-DNA in formalin-fixed,paraffin-embedded tissue |
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| Authors: | Maresa Montag Thomas J. F. Blankenstein Naim Shabani Ansgar Brüning Ioannis Mylonas |
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| Affiliation: | (1) First Department of Obstetrics and Gynaecology, Ludwig-Maximilians-University, Maistrasse 11, 80337 Munich, Germany;(2) Department of Obstetrics and Gynecology, Klinikum Neuperlach, Munich, Germany; |
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| Abstract: | ![]()
Introduction The role of human papilloma virus (HPV) in the pathogenesis of anogenital dysplasia is now conclusive. However, HPV detection in formalin-fixed and paraffin-embedded tissues remains controversial. Therefore, the aim of this study was to evaluate morphological changes directly in tissue specimens using a HPV-DNA detection system involving HPV in situ hybridisation. |
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