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Mammary gland specific expression of Brk/PTK6 promotes delayed involution and tumor formation associated with activation of p38 MAPK |
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| Authors: | Lofgren Kristopher A Ostrander Julie H Housa Daniel Hubbard Gregory K Locatelli Alessia Bliss Robin L Schwertfeger Kathryn L Lange Carol A |
| Affiliation: | (1) Department of Medicine (Division of Hematology, Oncology, and Transplantation), University of Minnesota, 420 Delaware St. SE, MMC 806, Minneapolis, MN 55455, USA;(2) Microbiology, Immunology and Cancer Biology Graduate Program, University of Minnesota, 420 Delaware St. SE, MMC 196, Minneapolis, MN 55455, USA;(3) Masonic Cancer Center, University of Minnesota, 425 E. River Road, Minneapolis, MN 55455, USA;(4) Department of Pathology, Third Faculty of Medicine, Ruska 87, 100 00 Praha 10, Czech Republic;(5) Department of Lab Medicine and Pathology, University of Minnesota, 420 Delaware St SE, MMC 609, Minneapolis, MN 55455, USA;(6) Department of Pharmacology, University of Minnesota, 321 Church St SE, Minneapolis, MN 55455, USA |
| Abstract: | IntroductionProtein tyrosine kinases (PTKs) are frequently overexpressed and/or activated in human malignancies, and regulate cancer cell proliferation, cellular survival, and migration. As such, they have become promising molecular targets for new therapies. The non-receptor PTK termed breast tumor kinase (Brk/PTK6) is overexpressed in approximately 86% of human breast tumors. The role of Brk in breast pathology is unclear. |
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