| Toll样受体4在肝脏缺血再灌注损伤和肝再生中的作用 |
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| 作者单位： | 中国医学科学院/中国协和医科大学药物研究所，中国医学科学院/中国协和医科大学药物研究所 |
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| 摘 要： | Toll样受体(TLR)是近年来倍受关注的一种病原识别受体,可特异地识别病原相关分子模式,通过激活信号级联反应产生细胞因子和相关刺激因子,从而在天然免疫和获得性免疫中发挥重要的桥梁作用。近年来,TLR4在肝脏缺血/再灌注(I/R)损伤等非病原微生物性炎症和肝再生中的作用也日益受到重视,已知其参与肝脏I/R损伤的部分炎症反应,但其是否参与肝再生过程有待进一步研究。
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| 关 键 词： | Toll样受体4 肝脏 缺血/再灌注 肝再生 |
Effect of Toll-like receptor 4 on liver ischemia/reperfusion injury and liver regeneration |
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| Yao Xiao-min,Li Yan. Effect of Toll-like receptor 4 on liver ischemia/reperfusion injury and liver regeneration[J]. Foreign Medical Sciences(Section of Pharmarcy), 2008, 0(4) |
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| Authors: | Yao Xiao-min Li Yan |
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| Abstract: | Toll-like receptor(TLR)is a family of pathogen recognition receptors that can recognize pathogen-associated molecular patterns(PAMPs),innate signal cascade reaction to produce cytokine and stimulating factors.Accordingly,TLR builds significantly bridge-effect between innate immunity and the adaptive immune response.TLR4 activation has been demonstrated to play a role in hepatic ischemia/reperfusion(I/R)injury and liver regeneration increasingly.Recently,multiple studies have shown that both inflammation and injury responses in hepatic I/R injury are partially TLR4 dependent,but whether and how TLR4 initiate liver regeneration is not clear. |
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| Keywords: | Toll-like receptor 4 liver ischemia/reperfusion liver regeneration |
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