Glioblastoma cells express functional cell membrane receptors activated by daily used medical drugs |
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| Authors: | Susanne A. Kuhn Ulrike Mueller Uwe-K. Hanisch Christian R. A. Regenbrecht Ilona Schoenwald Michael Brodhun Hartwig Kosmehl Christian Ewald Rolf Kalff Rupert Reichart |
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| Affiliation: | (1) Department of Neurosurgery, Medical Center, Friedrich-Schiller-University, Erlanger Allee 101, 07747 Jena, Germany;(2) SKP Services, Dresden, Germany;(3) Institute of Neuropathology, Medical Center, Georg-August-University, Goettingen, Germany;(4) Max-Planck-Institute of Molecular Genetics, Berlin, Germany;(5) Institute of Pathology, Helios Hospital, Erfurt, Germany |
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| Abstract: | Purpose Calcium ions are highly versatile spacial and temporal intracellular signals of non-excitable cells and have an important impact on nearly every aspect of cellular life controlling cell growth, metabolism, fluid secretion, information processing, transcription, apoptosis, and motility. Neurons and glia respond to stimuli, including neurotransmitters, neuromodulators, and hormones, which increase the intracellular calcium concentration. The function of intracellular calcium in gliomas is unknown. Lots of daily used drugs may act via receptors that can be linked to the intracellular calcium system and therefore could influence glioma biology. |
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