兔低位腹主动脉阻断后丙二醛(MDA)和超氧化物歧化酶(SOD)的观察

目的观察兔低位腹主动脉阻断后不同时间血液中丙二醛（MDA）和超氧化物歧化酶（SOD）的变化。方法建立兔腹主动脉阻断1、1．5h的模型，检测阻断前、再灌注不同时点血液中丙二醛（MDA）和超氧化物歧化酶（SOD）的变化。结果与对照组比较，阻断1h组（B1）再灌注时点血液中MDA升高、SOD降低不明显（P〉0．05），阻断1．5h组（B2）再灌注时点血液中MDA升高，SOD降低（P〈0．05）。结论兔低位腹主动脉阻断1h缺血再灌注损伤不明显，阻断1．5h有明显的缺血再灌注损伤。兔低位腹主动脉阻断应控制在1h以内。

Study of the MDA and SOD after low abdominal aortas blockage of the rabbits

Objective To study the changes of the MDA and SOD after low abdominal aortas blockage.Methods The model was established by clamping rabbit's abdominal aortas fof 1 hour and 1.5 hours,then samples of blood(MAD and SOD)were collected at different time points during reperfusion.Results Compared with the control group.the increase of blood MAD and the decrease of SOD were not obvious(P＞0.05)in 1 hour block group(B1).In the 1.5 hours blockage group(B2),blood MDA increased and SOD decreased(P＜0.05)when reperfused.Conclusion The blockage of rabbits abdominal aortas for 1 hour produced slight ischemic-reperfusion injury,.While 1.5 hours blockage produced serious ischemic-reperfusion injury,The blockage of rabbit abdominal sortas should control to within 1 hour.