启东乙肝干预研究30年随访人群烟酒嗜好、转氨酶及治疗史的横断面分析

目的 了解启东乙型肝炎干预研究队列人群在达到婚配年龄后的社会学人口特征、烟酒嗜好及疾病史信息。 方法 2013年1-10月采用横断面调查方法,分别对启东乙型肝炎干预研究的疫苗组与对照组研究对象分层随机抽样,采用自行设计的问卷收集研究对象的基本信息、个人生活习惯、疾病史等资料。 结果 共随访调查8 423人,疫苗组及对照组中男性分别占47.61%和46.62%,两组间男女性别差异无统计学意义(χ²=0.833,P=0.362)。两组男性目前吸烟率分别为48.36%和48.12%,差异无统计学意义(χ²=0.022,P=0.883)。疫苗组男性饮酒率22.84%低于对照组的28.87%,差异有统计学意义(χ²=18.844,P<0.001)。疾病史调查结果两组中2.86%和5.50%的研究对象有过转氨酶升高,差异有统计学意义(χ²=37.274,P<0.001),1.18%和2.13%的研究对象进行过抗乙肝病毒治疗,差异有统计学意义(χ²=7.124,P=0.008)。 结论 本次研究获得了研究对象的吸烟、饮酒、转氨酶及乙肝治疗史等重要信息,为肝癌及其他慢性病的病因研究提供了可靠资源;还需进一步优化问卷设计和实施,以获得更准确的流行病学信息。

Cross-sectional analysis on smoking and alcohol consumption,aminotransferase and treatment history of participants with 30-year follow-up of the Qidong Hepatitis B Intervention Study

Objective To investigate the socio-demographic characteristics, smoking and alcohol consumption and disease history of cohort participants with the marriage age from Qidong Hepatitis B Intervention Study (QHBIS). Methods A cross-sectional study was conducted among QHBIS participants from January to October in 2013, and the objects in the vaccine group and the control group were sampled by randomly stratified method. A self-designed questionnaire was used to collect the objects’ general information, personal habit, disease history and other data. Results A total of 8,423 participants were followed-up. The males in the vaccine group and the control group accounted for 47.61% and 46.62% respectively, and no statistically significant difference was found in the gender distribution between the two groups (χ²=0.833, P=0.362). The prevalence rates of current smoking in the males of the two groups were 48.36% and 48.12% respectively, showing no statistically significant difference (χ²=0.022, P=0.883). The prevalence rate of male alcohol consumption was lower in the vaccine group than in the control group (22.84% vs. 28.87%), with a statistically significant difference (χ²=18.844, P<0.001). The results of disease history survey revealed that 2.86% and 5.50% research objects in the two groups respectively had a history of elevated aminotransferase, showing a statistically significant difference (χ²=37.274,P<0.001). 1.18% and 2.13% research objects in the two groups respectively received anti-hepatitis B viral therapies, with a statistically significant difference (χ²=7.124, P=0.008). Conclusions We collect the important information regarding smoking and drinking habits, aminotransferase and history of hepatitis B treatment of QHBIS participants through this cross-sectional study, and the results provide reliable resources for exploring the etiology of liver cancer and other chronic diseases. It is necessary to optimize the design and implementation of the questionnaire so as to obtain more accurate epidemiological information.