“从肾论治”小儿癫痫的临床研究

[目的]评价益肾填精法治疗小儿癫痫强直-阵挛性发作的有效性与安全性。[方法]以强直-阵挛性发作患儿为研究对象,随机分为3组,分别予茸菖胶囊、抗痫胶囊、卡马西平治疗1年,观察患儿癫痫发作频率、持续时间、脑电图、中医证候、认知功能的测定及肝肾功能等安全性指标,进行疗效评定。[结果]在改善疾病疗效方面,三者效果相当（P〉0.05）;在改善中医证候方面,茸菖胶囊与抗痫胶囊疗效相当,均优于卡马西平（P〈0.05）;在改善认知功能方面,茸菖胶囊比抗痫胶囊及卡马西平具有突出的优势（P〈0.05）。[结论]以益肾填精法为主的茸菖胶囊具有抗痫与益智双重作用,安全有效,从而为小儿癫痫＂从肾论治＂提供了可靠的临床依据。

Clinical study on treatment from the kidney with pediatric epilepsy

[Objective] To evaluate the efficacy and safety of the method of tonifying kidney and essence replenishment in the treatment of pediatric epilepsy tonie-clonic seizure. [Method] In the study, children with Tonic - elonic seizures were randomly divided into three groups. They were treated with Chopped Chang capsule, anti-epilepsy capsule and Carbamazepine respectively for one year. Evaluate the efficacy through observing seizure frequency, duration, EEG Figure, syndrome, cognitive function, liver and kidney function and other security indicators. [Results] In the respect of improving disease curative effect, the three methods have similar effect （P〉0.05）. Chopped Chang capsule was similar to anti-epilepsy capsule but superior to Carbamazepine in the respect of improving syndrome of TCM （P〈0.05）. In the respect of improving cognitive function, Chopped Chang capsule was superior to anti-epilepsy capsule and Carbamazepine（P〈0.05）. [Conclusion]Chopped Chang capsule which based on the method of tonifying kidney and essence replenishment has dual function of anti-epilepsy and increasing the brainpower. It is safe and effective. The study has provided reliable clinical evidence for pediatric epilepsy treatment from the kidney aspect.