| 乙醇影响LPS易位和播散作用的研究进展 |
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| 引用本文： | 安妮,顾小飞,范晓明,郭昌星.乙醇影响LPS易位和播散作用的研究进展[J].中华全科医学,2012(6):933-934. |
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| 作者姓名： | 安妮 顾小飞 范晓明 郭昌星 |
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| 作者单位： | 第二军医大学研究生管理大队麻醉队;海军"和平方舟"号医院船医疗中心;第二军医大学研究生管理大队临床十队;第二军医大学长征医院急救科 |
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| 摘 要： | 乙醇相关性因素往往与慢性炎症相关。导致此类炎症的主因在于肠道微生物产生的脂多糖(LPS)。乙醇可影响肠道黏膜的完整性和通透性,导致肠道黏膜通透性增高、屏障结构缺损,显著增加LPS从肠道易位的概率。从肠道易位的LPS经胃肠道淋巴管和门静脉进入体循环,经门脉途径大部分LPS可被肝脏解毒,经淋巴途径则可有大量LPS进入体循环,进而导致全身性炎症反应的发生,可引起远端靶器官损害。LPS的播散途径还可以影响释放入循环系统的炎性介质的种类,进而影响个体的炎症反应状态。
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| 关 键 词： | 乙醇 脂多糖 |
Research Progress of Influence of Alcohol on Translocation and Dissemination |
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| Institution: | AN Ni,GU Xiao-fei,FAN Xiao-ming,et al.Anesthesiology Squadron,Postgraduates Administration Team,the Second Military Medical University,Shanghai 200433,China |
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| Abstract: | Chronic inflammation is commonly associated with alcohol-related medical conditions.The key inducer of those kinds of inflammation is the gut microflora-derived lipopolysaccharide(LPS).Alcohol can significantly increase the translocation of LPS from the gut.After passing through the gut epithelium,LPS can enter the systemic circulation by some routes,leading to persistent systemic inflammation and ultimately,to organ damage.This paper focuses on the translocation and dissemination of LPS passing through the gut epithelium,and introducing of the latest research progress of influence of LPS translocation and dissemination by alcohol. |
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| Keywords: | Alcohol Lipopolysaccharide |
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