2010年医院感染细菌的耐药性分析

目的 了解医院2010年1-12月全年临床分离菌株对各类抗菌药物的耐药性,以指导临床合理使用抗菌药物.方法 使用纸片扩散法进行抗菌药物监测,结果参照CLSI 2005年版进行判断.结果 临床分离1073株细菌中,革兰阳性菌占31.3％,革兰阴性菌占68.7％；耐甲氧西林金黄色葡萄球菌(MRSA)及耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)分别检出54.1％及65.3％,产ESBLs大肠埃希菌及肺炎克雷伯菌检出率分别为42.7％和28.9％.结论 该资料对医院细菌性感染的治疗和抗菌药物的合理选用具有重要的参考价值.

Analysis of drug resistance of bacteria causing nosocomial infections in 2010

OBJECTIVE To investigate the drug resistance of clinical isolates from the Ya′an people′ hospital from Jun.to Dec.2010,so as to guide the doctors to use antibacterial drugs rationally.METHODS Antimicrobial susceptibility testing of clinical isolates were performed using Kirby Bauer methods and the results were analyzed according to the standards recommended by CLSI/NCCLS.RESULTS Of 1073 clinical isolates Gram positive organisms accounted for 31.3%,Gram negative organisms for 68.7%.The detection rates of methicillin-resistant Staphylococcus aureus(MRSA) and coagulase-negative Staphylococci(MRCONS) were 52.8% and 64.3%,respectively.ESBLs producing E.coli strains accounted for 42.7% and Klebsiella pneumoniae strains for 28.9%.CONCLUSION The data of bacterial resistance is important and valuable for the guidance of rational selection of antimicrobial agents.