| 多药耐药肺炎克雷伯菌对利福平及磺胺甲噁唑/甲氧苄啶耐药机制的研究 |
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| 引用本文： | 朱健铭,姜如金,吴康乐,马兆龙.多药耐药肺炎克雷伯菌对利福平及磺胺甲噁唑/甲氧苄啶耐药机制的研究[J].中华医院感染学杂志,2012,22(3):452-456. |
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| 作者姓名： | 朱健铭 姜如金 吴康乐 马兆龙 |
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| 作者单位： | 杭州市余杭区中医院检验科,浙江杭州,311106 |
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| 基金项目： | 杭州市科技发展计划项目(20110833B48);杭州市卫生科技计划项目(2010B078);杭州市余杭区重大科技项目(2010001) |
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| 摘 要： | 目的 研究多药耐药肺炎克雷伯菌对利福平及磺胺甲噁唑/甲氧苄啶的耐药机制.方法 收集2008年8月-2010年5月浙江省杭州市和湖州市6所医院共47株肺炎克雷伯菌,采用聚合酶链反应(PCR)的方法分析1种利福平耐药相关基因和5种磺胺甲噁唑/甲氧苄啶耐药相关基因.结果 该组肺炎克雷伯菌共检出1种利福平耐药相关基因和3种磺胺甲噁唑/甲氧苄啶耐药相关基因.结论 携带1种利福平耐药相关基因和3种磺胺甲噁唑/甲氧苄啶耐药相关基因是该组菌对利福平和磺胺甲噁唑/甲氧苄啶耐药的一个重要原因.
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| 关 键 词： | 肺炎克雷伯菌 利福平 磺胺甲噁唑/甲氧苄啶 多药耐药 |
Resistance mechanisms of multidrug-resistant strains of Klebsiella pneumoniae to rifampicin and sulfamethoxazole/trimethoprim compound |
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| ZHU Jian-ming
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JIANG Ru-jin
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WU Kang-le
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Ma Zhao-long.Resistance mechanisms of multidrug-resistant strains of Klebsiella pneumoniae to rifampicin and sulfamethoxazole/trimethoprim compound[J].Chinese Journal of Nosocomiology,2012,22(3):452-456. |
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| Authors: | ZHU Jian-ming JIANG Ru-jin WU Kang-le Ma Zhao-long |
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| Institution: | (Hangzhou Yuhang Hospital of Traditional Chinese Medicine,Hangzhou,Zhejiang 311106,China) |
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| Abstract: | OBJECTIVE To investigate the resistance mechanisms of a group of multidrug-resistant Klebsiella pneumoniae to rifampicin and sulphamethoxazole/trimethoprim. METHODS From August 2008 to May 2010,47 strains of multidrug-resistant K.pneumoniae were collected from 6 hospitals in Hangzhou and Huzhou in Zhejiang province in China.One type of rifampicin-resistance gene and five types of sulphamethoxazole/trimethoprim-resistance genes were analyzed by PCR. RESULTS One type of rifampicin-resistance gene and three types of sulphamethoxazole/trimethoprim-resistance genes were detected in this group of K.pneumoniae. CONCLUSION Rifampicin-resistance gene and sulphamethoxazole/trimethoprim-resistance genes detected in this study play an important role in the resistance of K.pneumoniae to rifampicin and sulphamethoxazole/trimethoprim. |
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| Keywords: | Klebsiella pneumoniae Rifampicin Sulphamethoxazole/trimethoprim Multidrug-resistance |
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