肿瘤患者深部真菌耐药性分析

目的了解肿瘤患者深部真菌的耐药现状,为临床合理使用抗真菌药物提供依据。方法对2006年6月-2010年6月临床标本进行培养,用科玛嘉显色培养基或ATB鉴定卡作菌种鉴定,ATB-Fungus3药敏板进行药敏试验,并作回顾性分析和统计。结果分离到真菌386株,在痰液中检出率最多,占47.7%;真菌感染中以白色假丝酵母菌为主,占58.81%,其次为光滑假丝酵母菌占17.62%;分离的菌株对两性霉素B和5-氟胞嘧啶的耐药率均<10.00%,对氟康唑和伊曲康唑的耐药率较高。结论分离的菌株对常用抗真菌药物的耐药株增多,应加强对真菌耐药性的监测。

Drug resistance of deep fungi in cancer patients

OBJECTIVE To understand the situation of drug resistance of the deep fungi in cancer patients,to provide evidence for rational use of antifungal agents.METHODS From Jun.2006 to Jun.2010,clinical specimens were cultured,and CHROMager candida medium or ATB identification card were employed for strain identification.Susceptibility test was performed using the ATB-Fungus3 drug susceptibility plate.Retrospective and statistical analysis were performed.RESULTS Totally 386 strains of fungi were isolated.Detection rate was the highest in fungi isolated from the sputum,accounting for 47.7%;Candida albicans was the major pathogen in fungus infections,accounting for 58.81%,followed by C.glabrata,accounting for 17.62%.The drug resistance rates to amphotericin B and 5-fluorocytosine were less than 10.00% in isolated fungus,the resistance rates to fluconazole and itraconazol were higher.CONCLUSION Drug resistant strains of commonly used antifungal agents are increased in isolated fungus,the monitoring of drug resistance of fungi should be strengthened.