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阿糖胞苷对增殖期血管瘤中VEGF和PCNA表达的影响
引用本文:高永志,徐静,菜里,庞建华. 阿糖胞苷对增殖期血管瘤中VEGF和PCNA表达的影响[J]. 齐齐哈尔医学院学报, 2011, 32(9): 1365-1366
作者姓名:高永志  徐静  菜里  庞建华
作者单位:1. 哈尔滨医科大学附属第二医院美容整形科;齐齐哈尔医学院附属第一医院
2. 齐齐哈尔医学院附属第一医院
3. 哈尔滨医科大学附属第二医院美容整形科
摘    要:
目的探讨阿糖胞苷对增殖期血管瘤中血管内皮细胞生长因子(VEGF)和增殖细胞核抗原(PCNA)表达的影响。方法将27例增殖期血管瘤患儿随机分为对照组和实验组。实验组于瘤体注射药后21天手术切除瘤体,对照组直接手术切除瘤体。染色后,显微镜下观察瘤体组织中VEGF和PCNA的表达情况。结果实验组PCNA阳性表达率13.33%,VEGF阳性表达率20%;对照组PCNA阳性表达率83.33%,VEGF阳性表达率100%;两组之间的VEGF及PCNA表达差异显著(P〈0.01)。结论通过瘤体内注射阿糖胞苷后明显抑制增殖期血管瘤体组织中血管内皮细胞生长因子(VEGF)和增殖细胞核抗原(PCNA)表达,促进血管瘤体消退。

关 键 词:增殖期血管瘤  阿糖胞苷  VEGF  PCNA

The effect of expression of VEGF and PCNA in proliferating hemangioma by cytosine arabinoside
GAO Yong-zhi,et al.. The effect of expression of VEGF and PCNA in proliferating hemangioma by cytosine arabinoside[J]. Journal of Qiqihar Medical College, 2011, 32(9): 1365-1366
Authors:GAO Yong-zhi  et al.
Affiliation:GAO Yong-zhi,et al.(The Second Clinical School of Harbin Medical University,Harbin,Heilongjiang151000,the P.R.China)
Abstract:
Objective To explore the effect of expression of vascular endothelial growth factor(VEGF) and proliferating cell nuclear antigen(PCNA) in proliferating hemangioma which were used ytosine arabinoside. Methods Selected in the proliferative phase of hemangiomas of children with 27 cases,the children were randomly divided into control group and experimental group.After 21 days of treatment,the tumor was resected in experiment group by operation.The tumor in control group was resected directly.The specimen was s...
Keywords:VEGF  PCNA
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