急性脑梗死患者血清中Hey、NSE的临床研究

目的 研究急性脑梗死（ACI）患者治疗前、后血清同型半胱氨酸（Hcy）和神经元特异性烯醇化酶（NSE）水平的变化与意义.方法 应用化学发光法和双抗体夹心ELISA法对120例ACI患者治疗前、后进行血清Hcy和NSE水平测定.结果 ACI患者治疗后血清Hcy（5.6±1.5）μmol/L,明显低于治疗前的（18.8±3.2）μmol/L及对照组的（7.5±1.5）μmol/L,比较差异有显著性（P＜0.05）; ACI患者治疗后血清NSE（7.04±2.1）μg/L,明显低于治疗前的（21.06±4.6）μg/L,比较差异有显著性（P＜0.05）.结论 检测ACI患者血清Hcy和NSE水平对判断病情和预后有重要价值.

Serum levels of Hcy and NSE in patients with acute cerebral infarction

Objective To investigate the changes in serum levels of Hcy and Neuron-special enolas (NSE) after treatment in patients with acute cerebral infarction. Methods Serun Hcy levels were detected by chemiluminescence, and so were NSE levels by ELISA in 120 patients with cerebral infarction before and after treatment. Results Before treatment, serum levels of Hcy and NSE were significantly higher in the patients than in the healthy controls (P>0.05); and they were significantly diferent after treatment (P<0.05). Conclusions Detection of serum levels of Hcy and NSE plays an important role in estimating the disease course and predicting the prognosis