肝纤维化病程中Kupffer细胞与HSC的相互关系（综述）

肝纤维化（HF）是诸多慢性肝病共同的病理过程,也是各种慢性肝病向肝硬化转归的中转站。肝星状细胞（HSC）是细胞外基质（ECM）的主要来源,在肝纤维化形成中起关键性作用。枯否细胞（KC）是肝脏内重要的非实质细胞,KC通过分泌一系列细胞因子参与HSC的活化。参与肝纤维化的发生与发展。在肝纤维化的恢复阶段,KC可抑制HSC活性,促进其凋亡从而发挥抗纤维化作用。因此,深入研究Kupffer细胞与HSC的Cross-talk在肝纤维化的发生与发展中的作用和机制,对于临床工作中防治肝脏损伤,提高患者生存率具有实际意义。

Cross-talk between Kupffer Cells and HSC in the Pathogenesis of Liver Fibrosis

Hepatic fibrosis is the common pathologic process of varied chronic liver diseases and it is also atransfer stationfor many chronic liver diseases lapsing to cirrhosis.Extra cellular matrix(ECM),which plays a key role in the formation of liver fibrosis,mainly comes from the hepatic stellate cell(HSC).Kupffer cells(KC),a kind of nonparenchymal cells and defenders in the liver,Cytokines secreted by KC are Involved in the activation of HSC and the occurrence and progression of hepatic fibrosis.In the recovery ...