川崎病患儿血浆内皮素检测与冠状动脉病变

目的　了解川崎病 (KD)患儿血浆内皮素 (ET)在急性期和亚急性期变化 ,及其与KD及并冠状动脉病变的关系。方法　检测 5 0例KD患儿急性期和亚急性期血浆ET含量 ,并以 30例急性感染及 30例健康儿童作对照组。结果　 1.KD组亚急性期血浆ET较急性期显著增高 ;2 .KD组与健康对照组比较 ,急性期和亚急性期血浆ET均显著增高 ;与感染对照组相比 ,仅亚急性期显著增高 ;3.彩超探及KD组 5 4 %患儿冠状动脉扩张(CAD) ,其亚急性期血浆ET较无CAD组显著增高。结论　KD患儿亚急性期ET进一步增高 ,对发生冠状动脉及其他心血管并发症有一定提示 ,同时应作相关检查

Relationship of detection of serological endothelin and coronary artery lesion in children with kawasaki disease

Objective To investigate the alterations of serological endothelin(ET) in patients with kawasaki disease(KD) and its relation with coronary dilatation(CAD).Methods Serological ET were measured in 50 cases of patients with KD in acute phase as well as subacute phase; 30 cases of patients with acute febrile infection(IC) in infective phases and 30 healthy children(HC).Results 1.ET in subacute phase significantly increased than that in acute phase.2.In both acute and subacute phases of KD, ET significantly elevated higher than that in HC; and ET in subacute phase significantly elevated than that of IC. 3. Fifty-four percentage patients with KD were complicated with CAD. For CAD subgroup, ET had no difference with CAD subgroup in subacute phase.Conclusion ET has still increases in subacute of KD,which indicates the relation with coronary artery lesion.