Association of faecal elastase 1 with non-fasting triglycerides in type 2 diabetes |
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| Affiliation: | 1. Institute for Biometrics and Epidemiology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University, Auf''m Hennekamp 65, D-40225 Düsseldorf, Germany;2. MediStatistica, Neuenrade, Germany;3. AstraZeneca R&D, Mölndal, Sweden;4. Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden;5. MRC Epidemiology Unit, University of Cambridge, Cambridge, UK;1. Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany;2. Division of Interventional Pulmonary, Baylor Scott and White Hospital, Waxahachie, TX;3. Institute of Pathology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany;4. Department of Medical Oncology, West German Cancer Center, University Hospital Essen, University Duisburg-Essen, Essen, Germany;1. Gastroenterology and Gastrointestinal Endoscopy Unit, Division of Experimental Oncology, San Raffaele Scientific Institute IRCCS, Vita-Salute San Raffaele University, Milan, Italy;2. Pancreato-Biliary Endoscopy and Endosonography Division, Pancreas Translational & Clinical Research Center, San Raffaele Scientific Institute IRCCS, Vita-Salute San Raffaele University, Milan, Italy;1. Department of Gastroenterology and Pancreatology, Beaujon Hospital, AP-HP, Clichy, and Paris-Diderot University, Paris, France;2. Department of Radiology, Beaujon Hospital, AP-HP, Clichy, and Paris-Diderot University, Paris, France;3. Department of Pathology, Beaujon Hospital, AP-HP, Clichy, and Paris-Diderot University, Paris, France;1. Department of Radiology, Hebrew University Hadassah Medical Center, Jerusalem, Israel;2. Department of Pediatrics, Hebrew University Hadassah Medical Center, Jerusalem, Israel |
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| Abstract: | ![]()
AimsIntestinal absorption of esterified fatty acids depends on exocrine pancreatic function and influences plasma triglycerides levels. The aim was to investigate the association of reduced exocrine pancreatic function (low fecal elastase-1; FE1) with plasma triglycerides in type 2 diabetes and controls without diabetes.MethodsFE1 (μg/g stool) and non-fasting plasma triglyceride measurements were undertaken in 544 type 2 diabetes patients (age: 63 ± 8 years) randomly selected from diabetes registers in Cambridgeshire (UK), and 544 matched controls (age, sex, practice) without diabetes. Linear regression models were fitted using FE1 as dependent and log-triglycerides as independent variable adjusting for sex, age, body mass index, alcohol consumption, serum lipase, HbA1c, and smoking.ResultsFE1 concentrations were lower (mean ± SD: 337 ± 204 vs. 437 ± 216 μg/g, p < 0.05) and plasma triglycerides were higher (geometric mean */: standard deviation factor: 2.2*/:1.9 vs. 1.6*/:1.8 mmol/l, p < 0.05) in type 2 diabetes compared to controls, respectively. Within the category of type 2 diabetes and controls separately, a 10% increase in plasma triglycerides was associated with 4.5 μg/g higher FE1 concentrations (p < 0.01) after adjusting for confounders. In contrast, in diabetes patients and controls with pathological FE1 (<100 μg/g), low FE1 levels were associated with high plasma triglycerides (significant only in controls).ConclusionsNon-fasting triglycerides were positively related to FE1 in both type 2 diabetes and controls suggesting that impairment of exocrine pancreas function is influencing plasma triglycerides. Marked loss of exocrine pancreatic function had the opposite effect, resulting in higher levels of plasma triglycerides. |
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| Keywords: | Pancreatic exocrine dysfunction Faecal elastase 1 Triglycerides Type 2 diabetes Chronic pancreatitis Cardiovascular disease |
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