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Small,dense high-density lipoprotein 3 particles exhibit defective antioxidative and anti-inflammatory function in familial hypercholesterolemia: Partial correction by low-density lipoprotein apheresis
Affiliation:1. Université Pierre et Marie Curie-Paris 6, Paris, France;2. AP-HP, Groupe hospitalier Pitié-Salpétrière, Paris, France;3. National Institute for Health and Medical Research (INSERM), Paris, France;4. Hôpital Bicetre, Bicetre, France;1. Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland;2. Institute of Public Health and Clinical Nutrition, Clinical Nutrition, University of Eastern Finland, Kuopio, Finland;3. Institute of Clinical Medicine, Internal Medicine, Kuopio University Hospital, Kuopio, Finland;4. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland;5. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland;1. Department of Pediatrics, The Ohio State University College of Medicine, Columbus, Ohio, USA;2. Department of Internal Medicine, The Ohio State University College of Medicine, Columbus, Ohio, USA;3. Department of Surgery, The Ohio State University College of Medicine, Columbus, Ohio, USA;4. Center for Pediatric Transplant Research, Nationwide Children’s Hospital, Columbus, Ohio, USA;5. Section of Pulmonary Medicine, Nationwide Children’s Hospital, Columbus, Ohio, USA;6. Section of Cardiology, Nationwide Children’s Hospital, Columbus, Ohio, USA;7. Center for Perinatal Research, Nationwide Children’s Hospital, Columbus, Ohio, USA;8. Department of Anesthesiology and Pain Medicine, Nationwide Children’s Hospital, Columbus, Ohio, USA;9. Department of Anesthesiology, The Ohio State University College of Medicine, Columbus, Ohio, USA;1. Division of Nutrition and Metabolic Diseases, Center for Human Nutrition, UT Southwestern Medical Center, Dallas, TX, USA;2. Department of Internal Medicine, UT Southwestern Medical Center, Dallas, TX, USA;3. Department of Clinical Sciences, UT Southwestern Medical Center, Dallas, TX, USA;1. Centre for Molecular Nutrition and Chronic Diseases, Pontificia Universidad Católica de Chile, Santiago, Chile;2. Department of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile;3. Department of Public Health, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile
Abstract:
Keywords:Familial hypercholesterolemia  LDL apheresis  Small, dense HDL  Antioxidative activity  Anti-inflammatory activity  Lipid surface rigidity  Apolipoprotein A-I
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