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High expression of miR-195 is related to favorable prognosis in cytogenetically normal acute myeloid leukemia |
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| Authors: | Cui Longzhen Zeng Tiansheng Zhang Liyuan Liu Yan Wu Guangsheng Fu Lin |
| Affiliation: | 1.Translational Medicine Center, Huaihe Hospital of Henan University, Kaifeng, 475000, China ;2.Department of Hematology, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China ;3.Translational Medicine Center, State Key Laboratory of Respiratory Disease, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China ;4.Guangdong Provincial Education Department Key Laboratory of Nano-Immunoregulation Tumor Microenvironment, The Second Affiliated Hospital, Guangzhou Medical University, Guangzhou, 510260, China ;5.Peking University School of Medicine, Beijing, 100083, China ;6.Department of Hematology, First Affiliated Hospital, Medical College of Shihezi University, Shihezi, 832008, China ;7.Department of Hematology, Huaihe Hospital of Henan University, Kaifeng, 475000, China ; |
| Abstract: | Background Acute myeloid leukemia (AML) is a heterogeneous blood disease with poor treatment effect and high recurrence rate. With the deepening of non-coding RNA research, more and more miRNAs have been found to participate in various physiological processes of tumors. In this study, we tried to find the miRNA related to the prognosis of AML. MethodsCollect gene expression data and clinical information of AML patients in the Cancer Genome Atlas database for statistical analysis. The expression level of miR-195 of each patient was standardized by logCPM and then produced as a box plot according to subtype classification. TargetScan was used to predict the target genes of miR-195, and these genes were subjected to GO pathway enrichment analysis by Metascape. Differential miRNAs were screened through the DESeq2 package in the R language. Survival rates were estimated using the Kaplan–Meier method and the log-rank test. The multivariate Cox proportional hazard models of EFS and OS were established. ResultsWe found that the expression of miR-195 was the lowest in cytogenetically normal (CN-) AML, and high expression of miR-195 only promoted the prognosis of chemotherapy-only CN-AML patients (EFS: P?=?0.016; OS: P?=?0.035). Multivariate analysis showed that miR-195high was a favorable and independent factor for CN-AML (both P?Conclusion We found that high expression of miR-195 can increase prognosis time of chemotherapy-only CN-AML patients, providing a new possibility for treatment. |
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