纤溶酶原激活剂抑制物-1基因4G/5G多态性与特发性卵巢早衰的相关性

目的:探讨纤溶酶原激活剂抑制物-1(plasminogen activator inhibitor-1,PAI-1)基因启动子区4G/5G多态性与特发性卵巢早衰(premature ovarian failure,POF)发病的关系。方法:应用PCR-RFLP分析,检测65例特发性POF患者(POF组)和75例正常妇女(对照组)PAI-1基因4G/5G多态性。结果:特发性POF患者组PAI-1基因型频率分布,4G/4G型为29.2%,4G/5G型为55.4%,5G/5G型为 15.4%;POF患者组4G/4G基因型频率明显高于对照组(16.0%),但差异无显著性意义(x2=3.54,P>0.05);而4G等位基因频率(0.569)显著高于对照组(0.447)(x2=4.18,P<0.05),携带4G等位基因个体发生特发性POF的相对风险OR= 1.64,95%CI1.02～2.64。结论:PAI-1基因4G/5G多态性与特发性POF的发病有关,4G等位基因可能是特发性POF发病的危险因素之一。

Relationship between plasminogen activator inhibitor-1 gene 4G/5G polymorphism and idiopathic premature ovarian failure

Objective To investigate the relationship between plasminogen activator inhibitor-1 (PAI-1)gene promoter region 4G/5G polymorphism and idiopathic premature ovarian failure(POF). Methods The 4G/5G polymorphism of PAI-1 gene in 65 patients with POF (POF group) and 75 healthy volunteer (control group) were detected by a combination of polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The genotype frequencies of PAI-1 gene in POF group was 29.2% for 4G/4G, 55.4% for 4G/5G an...