Collagen alteration in vascular remodeling by hemodynamic factors |
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Authors: | Y Ishikawa Noriko Asuwa Toshiharu Ishii Kinji Ito Yoshikiyo Akasaka Takao Masuda Lijun Zhang Hideko Kiguchi |
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Institution: | (1) Department of Pathology, Toho University School of Medicine, 5-21-16 Omori-nishi, Ohta-ku, Tokyo 143-8540, Japan Tel.: +81-3-37624151, Fax: +81-3-54935414, JP;(2) Department of Pathology, Hachioji Medical Center, Tokyo Medical University, 1163 Tatemachi, Hachioji City, Tokyo193-8639, Japan, JP;(3) Department of Pathology, Saiseikai Kanagawaken Hospital, 6-6 Tomiya-cho, Kanagawa-ku, Yokohama 221-0821, Japan, JP |
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Abstract: | The collagen alterations in the vascular wall remodeled by hemodynamic change were investigated by electron microscopy and
immunohistochemistry. The left anterior descending coronary artery (LAD) without a myocardial bridge (MB) showed both lower
matrix metalloproteinase-1 (MMP-1) expression and a smaller extent of spiraled collagen (SC) distribution than the LAD wall
with MB, in which the intima was influenced by high shear stress. In the wall of the varicose great saphenous vein (GSV) the
expression of MMP-1 was lower, while the expression of prolyl 4-hydroxylase was higher, than in the normal GSV. The extent
of SC distribution in the intima and media of the varicose GSV was smaller than that in the normal GSV. An analogous difference
in results was demonstrated between the portal vein (PV) of patients with liver cirrhosis and normal PV. However, the levels
of expression of MMP-2, MMP-9 and tissue inhibitors of MMP (TIMPs) in these pathologic vessels were not different from those
in the corresponding normal vessels. The results indicate that hemodynamic forces such as shear stress and increased intravascular
blood pressure contribute to the collagen alterations in the vascular wall, which may lead to vascular wall remodeling.
Received: 22 October 1999 / Accepted: 20 January 2000 |
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Keywords: | Hemodynamic factor Human blood vessel Matrix metalloproteinases Spiraled collagen Collagen metabolism |
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