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| CD+4 CD+25调节T细胞的生物学功能及其在移植物抗宿主病中作用的研究进展 | |
| 引用本文： | 任瑞瑞,牛燕燕,MA Liang-ming. CD+4 CD+25调节T细胞的生物学功能及其在移植物抗宿主病中作用的研究进展[J]. 肿瘤研究与临床, 2010, 22(10): 718-720. DOI: 10.3760/cma.j.issn.1006-9801.2010.10.029 |
| 作者姓名： | 任瑞瑞 牛燕燕 MA Liang-ming |
| 作者单位： | 1. 山西医科大学第二临床医院血液科,太原,030001 2. Department of Hematology, the Second Clinical Medical College, Shanxi Medical University,Taiyuan 050001, China |
| 摘 要： | CCD+4 CD+25 调节T（Treg）细胞具有免疫无能性和免疫抑制性两大功能特征，是抑制性T细胞的一种亚群。能抑制效应细胞CD+4 T细胞和CD+8 T细胞的活化与增殖，从而有效抑制免疫系统对外来器官产生的排异反应，减轻了造血干细胞移植（HSCT）术后移植物抗宿主病（GVHD），而且不影响移植物抗白血病（GVL）效应，从而在移植免疫耐受中发挥重要的作用。 |
| 关 键 词： | 移植物抗宿主病 CD4+CD25+调节T细胞 异基因造血干细胞移植 |
| 收稿时间： | 2009-12-07 |
Research advances of CD+4CD+25 Treg cell and it's function in GVHD |
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| REN Rui-rui,NIU Yan-yan,MA Liang-ming. Research advances of CD+4CD+25 Treg cell and it's function in GVHD[J]. Cancer Research and Clinic, 2010, 22(10): 718-720. DOI: 10.3760/cma.j.issn.1006-9801.2010.10.029 | |
| Authors: | REN Rui-rui NIU Yan-yan MA Liang-ming |
| Affiliation: | REN Rui-rui, NIU Yan-yan, MA Liang-ming.( Department of Hematology, the Second Clinical Medical College, Shanxi Medical University, Taiyuan 030001, China) |
| Abstract: | CD+4 CD+25 regulatory T cell (Treg) has immune incompetent and immune suppression functions, and is a kind of suppressor T-cell subsets. It can inhibit the activation and proliferation of CD+4 T cells and CD+8 T cells, so as to effectively suppress the immune system to foreign organ and reduce the graftversus-host disease (GVHD) after hematopoietic stem cell transplantation (HSCT), without affecting the role of graft-versus-leukemia (GVL), which plays an important role in the transplantation immune tolerance. |
| Keywords: | Graft-versus-host disease CD+4 CD+25 regulatory T cells Allo-HSCT |
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