Assessment of IgE-mediated food allergies in children with atopic dermatitis |
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| Affiliation: | 1. Allergy Unit of the 3rd Pediatric Department, Aristotle University of Thessaloniki, Greece;2. Department of Pediatrics, Democritus University of Thrace, Greece;3. Immunology Unit 1st Pediatric Department, Aristotle University of Thessaloniki, Greece;4. Organ Transplantation Unit, Aristotle University of Thessaloniki, Greece;5. 4th Pediatric Department, Aristotle University of Thessaloniki, Greece;1. Department of Allergology, Gregorio Marañón University Hospital, Madrid, Spain;2. Section of Pediatric Immunology, Gregorio Marañon Maternal-Children''s Hospital, Madrid, Spain;1. Extrahospitalary Paediatric Emergency Service, Osasunbidea, Pamplona, Navarra, Spain;2. Department of Health Sciences, Public University of Navarra, Spain;3. Preventive Medicine, Clínica Universidad de Navarra, Pamplona, Navarra, Spain;4. Navarra Institute for Health Research (IdiSNA), Spain;5. Paediatric Endocrinology Unit, Department of Pediatrics, Clínica Universidad de Navarra, Pamplona, Navarra, Spain;1. Servicio de Alergia e Inmunología Clínica Pediátrica, Hospital Infantil de México Federico Gómez, México, DF, Mexico;2. Subdirección de Pediatria Ambulatoria, Hospital Infantil de México Federico Gómez, México, DF, Mexico;1. Respiratory and Allergy Units, Arrixaca Children''s University Hospital, University of Murcia, Spain;2. IMIB Bio-Health Research Institute, Spain;1. Department of Pediatric Gastroenterology, Hepatology and Nutrition, Turkish Republic Health Ministry, Ankara Child Health Diseases, Haematology Oncology Training and Research Hospital, Ankara, Turkey;2. Department Pediatric Allergy and Immunology, Turkish Republic Health Ministry, Ankara Child Health Diseases, Haematology Oncology Training and Research Hospital, Ankara, Turkey |
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| Abstract: | BackgroundAtopic dermatitis (AD) is an inflammatory disease of the skin, which is characterised by a chronic relapsing course.AimThe aim of the study was to assign the prevalence of clinically active food allergies among a group of children between 3 months and 7 years of age, with AD.MethodsEighty-eight children with AD were screened for specific IgE antibodies to food proteins. All patients with AD and specific IgE antibodies to food proteins were subjected to Oral Food Challenges (OFCs) with the relevant foods.ResultsFood-sensitised patients with moderate levels of sIgE had clinically active food allergy to milk (39.28%) and egg (42.34%) on the basis of positive OFCs. High IgE and eosinophilia had a prevalence of almost 80% and 25%, regardless of concomitant food sensitisation and disease severity.ConclusionsIn this study, clinically active food allergies were recognised in 26.13% of children with AD. Nevertheless, no association was confirmed between food sensitisation and AD severity. High IgE and peripheral eosinophilia have not been found more prevalent among children with severe AD nor among children with food sensitisation. Infants and younger children with AD should be screened for an underlying food allergy, regardless of disease severity. |
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| Keywords: | Atopic dermatitis Children Eczema Food allergy Food hypersensitivity reactions |
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