广东省中山市急性发热呼吸道症候群病毒病原学研究

目的 获得中山市急性发热呼吸道症候群病毒病原谱,为疾病防控及临床诊疗提供科学依据。方法 2017年12月至2018年11月,选择中山市4家医疗机构作为哨点监测医院,在门诊开展季节性流感等发热呼吸道症候群监测。采用多重RT-PCR方法检测8 种呼吸道感染病毒。结果 累计检测样本1 011份,368份（36.4%）检出病毒阳性。不同病毒检出阳性率依次为：流感病毒（Flu）14.0%,腺病毒（AdV）6.3%,鼻病毒（hRV）5.9%,呼吸道合胞病毒（RSV）4.9%,冠状病毒（hCoV）3.1%,副流感病毒（PIV）2.4%,人偏肺病毒（HMPV）2.0%和博卡病毒（hBoV）1.2%。与16岁及以上人群相比,16岁以下人群病毒检出率更高（27.3% VS 44.7%,χ²=32.867, P<0.001),病毒感染种类更加多样化。5岁及以下婴幼儿8种病毒均有检出,其中呼吸道合胞病毒（9.2%,37/404）、腺病毒（9.7%,39/404）检出率最高。6~15岁人群,流感病毒检出率(29.8%)最高。除副流感病毒和博卡病毒外,其余病毒不同月份检出率存在差异。结论 流感病毒、腺病毒、鼻病毒和呼吸道合胞病毒是中山市发热呼吸道症候群的主要病原体;年龄组越小,病毒多样性越明显;不同病原体其感染季节不尽相同,但多数病原体以冬季流行感染为主。

Viral etiologies of acute febrile respiratory syndrome in Zhongshan,Guangdong

Objective In order to obtain the pathogenic spectrum of acute febrile respiratory syndrome virus in Zhongshan City, and we provide scientific basis for disease control and clinical diagnosis and treatment. Methods Four medical institutions in Zhongshan City were selected as sentinel monitoring hospitals to carry out febrile respiratory syndrome monitoring in outpatient clinics from December 2017 to November 2018, and 8 species of respiratory virus were detected by multiple RT-PCR. Results A total of 1 011 samples were tested, and 368 (36.4%) were positive. The positive detection rates of different viruses were respectively: influenza virus (Flu) 14.0%, adenovirus (AdV) 6.3%, rhinovirus(hRV) 5.9%, respiratory syncytial virus(RSV) 4.9%, coronavirus(hCoV) 3.1%, parainfluenza virus (PIV) 2.4%, human metapneumovirus (HMPV) 2.0% and bocavirus (hBoV) 1.2%. Compared to people ≥16 years, virus detection rates were higher in people <16 years.（27.3% VS 44.7%,χ²=32.867, P<0.001), and virus infections were more diverse. All 8 kinds of viruses were detected in infants under 5 years old, among which respiratory syncytial virus（9.2%,37/404） and adenovirus（9.7%,39/404） had the highest detection rates. Among people aged 6-15 years, the detection rate of influenza virus was the highest (29.8%). Except for parainfluenza virus and bocavirus, the detection rates of other viruses were different in different months. Conclusions The most common pathogens of febrile respiratory syndrome were influenza virus, adenovirus, rhinovirus, respiratory syncytial virus in Zhongshan City; The younger the age group are, the more diverse the virus are;Different pathogens have different infection seasons, but most pathogens are mainly infected in winter.