《五大洲癌症发病》数据库2003-2012年北京市户籍居民原发性眼部恶性肿瘤发病情况分析

目的 分析《五大洲癌症发病》（Cancer Incidence in Five Continents，CI5）数据库北京市户籍居民原发性眼部恶性肿瘤的发病特征。设计 横断面研究。研究对象 世界卫生组织CI5数据库公布的2003年1月1日至2012年12月31日北京市户籍人口的眼部恶性肿瘤登记数据。方法 从CI5数据库中提取北京市户籍居民原发性眼部恶性肿瘤（ICD10: C69、C41.0、C49.0、C43.1、C44.1和C72.3）个案信息，结合北京市公安局人口处公布的2003-2012年10年间的人口数据，计算北京市户籍居民原发性眼部肿瘤发病率及世界标准人口构成标化发病率，对不同亚部位的眼部恶性肿瘤的构成特征和病理类型进行分析描述。主要指标 发病率及世界标准人口构成标化发病率。结果 10年间北京市户籍居民中共确诊原发性眼部恶性肿瘤患者740例，平均发病年龄为56.5±17.6岁（6个月~96岁），人群发病率为6.11/百万，男女性发病例数之比为1.2﹕1。原发性眼部肿瘤病理类型以基底细胞癌为主（27.3%），其次是腺癌、肉瘤、视网膜母细胞瘤和恶性黑色素瘤，分别占13.2%、11.8%、10.9%和8.8%。眼睑为眼部肿瘤的最好发部位（68.3%），其次是眼球（18.3%）和眼眶（4.8%）。10年间，无论是男性女性，不同年龄组眼部恶性肿瘤发病构成均无统计学意义（P均>0.05）。结论 CI5数据库公布的北京市户籍居民原发性眼部恶性肿瘤人群发病率6.11/百万，平均发病年龄（56.5±17.6）岁，最主要的病理类型为基底细胞癌，其次为腺癌、肉瘤、视网膜母细胞瘤和恶性黑色素瘤，眼睑为首位受累部位。

Analysis on incidence of primary ocular malignant tumor in Beijing household registration according to database of World Health Organization's Cancer Incidence in Five Continents

Objective To analyze the incidence characteristics of primary ocular malignant tumor in Beijing household registration according to database of World Health Organization's Cancer Incidence in Five Continents (CI5). Design Cross-sectional study. Participants Cancer registration data of Beijing registered population from January 1, 2003 to December 31, 2012 published by the World Health Organization's CI5 database. Methods Using the database information, combined with each annual demographic data provided by the Beijing Municipal Public Security Bureau, Beijing residents primary ocular tumor incidence and world standard demographic standardized incidence were calculated. The sites and pathological subtypes were analyzed. Main Outcome Measures Incidnece and standardized incidence of world standard population composition. Results According to the database, in the past 10 years, 740 patients with primary ocular malignant tumors were diagnosed in Beijing, with a population incidence of 6.11/million, the average age is 56.5 ± 17.6 years old, from 6 months old to 96 years old. Male/female is 1.2:1. The main pathological types were basal cell carcinoma (27.3%), followed by adenocarcinoma, sarcoma, retinoblastoma, and malignant melanoma, accounting for 13.2%, 11.8%, 10.9%, and 8.8%, respectively. Eyelid is the leading attacked site (68.3%), followed by eyeballs (18.3%) and orbits (4.8%). Within 10 years, no matter male or female, the incidence of ocular malignant tumors in different age groups was not statistically significant (all P>0.05). Conclusion According to the database, the incidence of primary ocular malignant tumor in Beijing residents registered in CI5 is 6.11/million, and the average age is 56.5±17.6 years. The top pathological types are basal cell carcinoma, followed by sebaceous gland carcinoma, sarcoma, retinoblastoma and malignant melanoma. Eyelid is the leading attacked site.