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| 免疫蛋白酶体在病毒感染中的作用 | |
| 引用本文： | 徐忆莲,刘琼,黄孝天. 免疫蛋白酶体在病毒感染中的作用[J]. 中国人兽共患病杂志, 2020, 36(10): 873-875. DOI: 10.3969/j.issn.1002-2694.2020.00.127 |
| 作者姓名： | 徐忆莲 刘琼 黄孝天 |
| 作者单位： | 南昌大学基础医学院微生物教研室,南昌 330006 |
| 基金项目： | 国家自然科学基金(No.31660035)和江西省自然科学基金项目(No.20171ACB20003)联合资助 |
| 摘 要： | 蛋白酶体是细胞内存在的一种多亚基复合物,对真核细胞内环境的稳态有着至关重要的作用。其中,免疫蛋白酶体是能够调控炎症因子、参与MHC-I抗原提呈路径的一类特殊蛋白酶体。本文对近年来免疫蛋白酶体在病毒复制、免疫逃逸、致病性以及抗病毒治疗等方面的研究进展进行综述,为设计新型抗病毒药物提供新思路。 |
| 关 键 词： | 蛋白酶体 免疫蛋白酶体 病毒复制 免疫逃逸 抗病毒治疗 |
| 收稿时间： | 2020-04-01 |
The role of immunoproteasomes in viral infection |
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| XU Yi-lian,LIU Qiong,HUANG Xiao-tian. The role of immunoproteasomes in viral infection[J]. Chinese Journal of Zoonoses, 2020, 36(10): 873-875. DOI: 10.3969/j.issn.1002-2694.2020.00.127 | |
| Authors: | XU Yi-lian LIU Qiong HUANG Xiao-tian |
| Affiliation: | Deparment of Medical Microbiology, Nanchang University, Nanchang 330006, China |
| Abstract: | Proteasome is a multi-subunit complex existing in cells and plays a vital role in the homeostasis of eukaryotic cells. While immunoproteasomes are a class of proteasomes that can regulate the production of inflammatory cytokines, participate in the MHC-I antigen presentation pathway. This article mainly reviewed the recent research progress of immunoproteasomes in viral replication, immunity escape, pathogenicity and antiviral therapy. Which will be helpful for providing new insight for the design of new antiviral drug. |
| Keywords: | proteasome immunoproteasome viral replication immunity escape antiviral therapy |
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