HLA typing in non-Hodgkin's lymphomas: Comparative study in Caucasoids, Mexican-Americans and Negroids |
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| Authors: | J. G. van den T weel D. J. Dugas J. Loon R. J. Lukes |
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| Affiliation: | Department of Pathology, USC School of Medicine and Los Angeles County-University of Southern California Medical Center, Los Angeles, California, USA;Department of Pathology, De Wever Hospital, Heerlen, The Netherlands, and;Department of Surgery, UCLA School of Medicine, Los Angeles, California, USA |
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| Abstract: | ![]()
Over 200 cases of non-Hodgkin's lymphoma were typed for HLA-A, B, C and DR antigens, and typing was correlated with the morphologic diagnosis according to the Lukes-Collins classification system of non-Hodgkin's lymphomas. Three major racial groups were represented: Caucasoids, Mexican-Americans and Negroids. Significant associations were observed between HLA-AW33 and Caucasoid B-cell lymphomas, and for HLA AW24, HLA-B37 and HLA-B40 and B cell lymphomas in Negroids. No significant correlations were found within the Mexican-American patient population. The number of T cell lymphomas was insufficient to draw any conclusions. The DR antigens were not significantly associated with any of the diagnostic subgroups. |
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