奥沙利铂联合5-FU／CF方案治疗晚期结肠癌的临床观察

目的：评价奥沙利铂（L～OHP）联合5-FU／CF方案治疗晚期结肠癌的临床疗效和不良反应。方法：43例晚期结肠癌患者，给予L—OHP130mg／m。静脉滴注，持续4h，d1；CF150mg／m^2静脉滴注，持续2h，d1-d5；5-FU500mg／m^2静脉滴注，持续6h，d1-d5。每3周重复1次。结果：43例患者中，完全缓解（CR）1例，部分缓解（PR）11例，稳定（SD）17例，进展（PD）11例，总有效率（CR＋PR）34．9％。不良反应主要是末梢神经毒性、恶心呕吐、腹泻、骨髓抑制等，均可耐受。结论：L—OHP联合5-FU／CF方案治疗晚期结肠癌疗效好，不良反应主要是末梢神经毒性和胃肠道反应。

Clinical observation of Oxaliplatin plus 5 - FU/CF in the treatment of advanced colorectal cancer

Objective ：To evaluate the therapeutic effect and toxicity of oxaliplatin plus 5 - FU/CF in the treatment of advanced colorectal cancer. Methods ： Forty three patients with advanced colorectal cancer received L - OHP plus 5 -FU/CF. L- OHP 130mg/m^2 was administered,iv infusion 4h,d1 ;leucovorin （CF） 150mg/m^2 ,iv infusion for 2h, d1 -5 ;followed by 5 - FU 500mg/m2 ,iv infusion over a period of 6h ,d1 -5. This regimen was repeated every 3 weeks. Results：Among 43 patients,there were 1 CR,14 PR,17 SD and 11 PD,the overall response rate （CR ＋ PR） was 34.9%. The major toxicities were nausea and vomiting, neurosensory toxicity and neutropenia, but they were tolerable. Conclusion：The combination of oxaliplatin and 5 - FU/CF is an effective and tolerable regimen for treatment of advanced colorectal cancer.