Transmission of avian influenza virus (H3N2) to dogs |
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Authors: | Song Daesub Kang Bokyu Lee Chulseung Jung Kwonil Ha Gunwoo Kang Dongseok Park Seongjun Park Bongkyun Oh Jinsik |
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Affiliation: | *Green Cross Veterinary Products Company, Ltd., Yong-in, South Korea;†Daewoong Pharmaceutical Company, Ltd., Yong-in, South Korea;‡Animal Genetics, Inc., Suwon, South Korea;§Seoul National University, Seoul, South Korea;1These authors contributed equally to this article. |
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Abstract: | In South Korea, where avian influenza virus subtypes H3N2, H5N1, H6N1, and H9N2 circulate or have been detected, 3 genetically similar canine influenza virus (H3N2) strains of avian origin (A/canine/Korea/01/2007, A/canine/Korea/02/2007, and A/canine/Korea/03/2007) were isolated from dogs exhibiting severe respiratory disease. To determine whether the novel canine influenza virus of avian origin was transmitted among dogs, we experimentally infected beagles with this influenza virus (H3N2) isolate. The beagles shed virus through nasal excretion, seroconverted, and became ill with severe necrotizing tracheobronchitis and bronchioalveolitis with accompanying clinical signs (e.g., high fever). Consistent with histologic observation of lung lesions, large amounts of avian influenza virus binding receptor (SAalpha 2,3-gal) were identified in canine tracheal, bronchial, and bronchiolar epithelial cells, which suggests potential for direct transmission of avian influenza virus (H3N2) from poultry to dogs. Our data provide evidence that dogs may play a role in interspecies transmission and spread of influenza virus. |
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Keywords: | influenza virus H3N2 dog avian research |
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