Peripheral blood CD5-positive B lymphocytes (B-1a cells) after allogeneic stem cell transplantation for acute myeloid leukaemia in humans |
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| Authors: | Dino Veneri Massimo Franchini Donata de Sabata Silvia Ledro Antonio Vella Riccardo Ortolani Giovanni Pizzolo Fabio Benedetti |
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| Affiliation: | 1 Dipartimento di Medicina Clinica e Sperimentale, Sezione di Ematologia, Università di Verona;;2 Servizio Trasfusionale, Azienda Ospedaliera di Verona;;3 Dipartimento di Patologia, Sezione di Immunologia, Università di Verona, Italy |
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| Abstract: | ![]()
BackgroundOnly few data are available in literature regarding the reconstitution of B-1a cells after allogeneic bone marrow transplantation performed for haematological malignancies.MethodsIn this study we used flow cytometry to assess the reconstitution of the peripheral blood B-1a cell compartment after allogeneic peripheral blood stem cell transplantation. Cytometric analyses were performed over time on 11 consecutive patients undergoing allogeneic peripheral blood stem cell transplantation for acute myeloid leukaemia in our Haematology Unit and the results were compared with available data regarding B-1a cell reconstitution after allogeneic bone marrow stem cell transplantation.ResultsIn spite of an earlier recovery of B-1a cells in the peripheral blood after allogeneic bone marrow transplantation, the reconstitution of this B-cell subset was similar, regardless of the source of stem cells employed.ConclusionsFurther studies are necessary in order to clarify the origin of B-1a cells in humans in health and illness. |
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| Keywords: | B-1a cells reconstitution stem cell transplantation |
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