前列腺小细胞癌3例报告并文献复习

目的 探讨前列腺小细胞癌的临床、病理特征及治疗方法.方法 回顾性分析3例前列腺小细胞癌患者的临床资料并复习文献.结果 2例术后病理诊断为前列腺小细胞癌,1例经直肠穿刺活检示前列腺小细胞癌,切片见肿瘤呈弥漫性片、巢状结构,伴大片凝固性坏死.核小、燕麦状或圆形、染色深、核仁不明显、胞质少,类似肺小细胞癌.例1行免疫组化染色检查:LCA、L-26、34 B E12、P504s(-),PSA、AE1/AE3、AR(+),CA、S.100(±).例l术后3个月死于全身广泛转移,例2术后13个月死于肺转移,例3术后5个月,仍在随访中.结论 前列腺小细胞癌是一种少见的高度恶性的肿瘤,确诊主要依靠病理诊断,早期即可发生转移,预后较差.目前尚无较满意的治疗方法.

Small cell carcinoma of the prostate (report of 3cases and review of the literature)

Objective To evaluate the clinical and pathological characteristics, as well as treatment of small cell carcinoma of the prostate. Methods Three patients with small cell carcinoma of the prostate were reported. Results Two cases small cell carcinoma were further confirmed by postoperative pathological analysis and 1 case proved by Per rectum puncture biopsy. Microscopically, the tumor cells arranged in solid-sheet and nest structures and exhibited a histological type of diffuse infiltrative carcinoma under microscope. Coagulated necrosis was easily observed. Small round or oval cells resembling lymphocytes or oat cells were the main constituents of the tumor. The nuclei were extremely hyperchromatic and scanty. The immunohistochemical staining results of case 1 were negative for LCA, L-26, 34 3 El2 and P504s, but positive for PSA, AEI/AE3 and AR, and suspected positive for CA and S-100. Case 1 died of widespread metastasis 3 month after operation. Cases 2 died of lung metastastic 13 months after operation. Cases 3 was in follow up now after operation. Conclusion Small cell cancer of the prostate is rare but can be diagnosed properly based on pathological features. Metastasis can emerge in earlier period. There is no effective treatment now and the prognosis is poor.