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角质的免疫组织化学定位在头颈肿瘤病理论断中的应用
引用本文:石善溶,Max L.Goodman,Atul K.Bhan,Ben Z.Pilch. 角质的免疫组织化学定位在头颈肿瘤病理论断中的应用[J]. 四川大学学报(医学版), 1986, 0(2)
作者姓名:石善溶  Max L.Goodman  Atul K.Bhan  Ben Z.Pilch
作者单位:华西医科大学附属一医院耳鼻喉科学教研室(石善溶),美国马萨诸塞眼耳鼻喉医院耳鼻喉病理室(Max L.Goodman),美国马萨诸塞总医院病理科(Atul K.Bhan),美国马萨诸塞眼耳鼻喉医院耳鼻喉病理室(Ben Z.Pilch)
摘    要:
本研究报告100例头颈正常及肿瘤组织石蜡切片的角质抗体定位。结果表明上呼吸、消化道之被覆上皮、涎腺导管、耵聍腺及中耳上皮、毛囊及汗腺等上皮组织均阳性,而间叶组织则为阴性。鳞癌、基底细胞癌等上皮源性肿瘤均为阳性。再次肯定了角质抗体定位的诊断价值。

关 键 词:抗角质抗体  免疫组织化学  角质抗体定位  上呼吸、消化道

PATHOLOGICAL DIAGNOSIS OF HEAD AND NECK TUMORS USING IMMUNOHISTOCHEMICAL LOCALIZATION OF KERATIN
Shi Shanrong,Goodman ML,Bhan AK,Pilch BZ,Chen-LB. PATHOLOGICAL DIAGNOSIS OF HEAD AND NECK TUMORS USING IMMUNOHISTOCHEMICAL LOCALIZATION OF KERATIN[J]. Journal of Sichuan University. Medical science edition, 1986, 0(2)
Authors:Shi Shanrong  Goodman ML  Bhan AK  Pilch BZ  Chen-LB
Affiliation:Shi Shanrong,Goodman ML,Bhan AK,Pilch BZ,Chen-LB Department of Otorhinolaryngology,West China University of Medical Sciences ENT Pathology,Massachusetts Eye and Ear Infirmary USA Department of Pathology,Massachusetts General Hospital USA Dana-Farber Cancer Institute,USA
Abstract:
Animal experiments and human surgicalpathology studies have shown that immu-nohistochemical localization of keratin maybe useful as a diagnostic parameter. Thisarticle is a study of keratin antibody locali-zation based on 100 cases of head and necknormal tissues as well as tumors by usingparaffin sections taken from the Massa-chusetts Eye and Ear Infirmary in theUnited States. The results show the following normaland tumor tissues of the head and neckregion stained positively for antikeratinantibody: Covered epithelium of the upperaerodigestive tract, ducts of salivary glands,ceruminous glands of. the ear canal, middleear mucosa, hair follicles and sweat glands;squamous cell carcinoma, basal cell carcino-ma and some other epithelial origin tumors.Our results confirm the value of keratinantibody localization in surgical pathology.
Keywords:Anti-keratin antibody  Immunohistochemistry  Keratin antibodylocalization  Upper aerodigestive tract
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