儿童侵袭性真菌感染的诊治进展

对于有原发性免疫缺陷病及各种继发性免疫功能低下的儿童,尤其是危重的住院患儿,侵袭性真菌感染逐年增多,病死率很高。所以应该重视感染的高危因素,尽早作相关的影像学检查(如胸部CT扫描),并且结合各种快速、准确的实验室检测:标本的直接镜检,真菌培养;聚合酶链反应;血清抗原测定(如1,3β--D-葡聚糖、曲霉半乳甘露聚糖、隐球菌荚膜多糖抗原等),综合分析,早期诊断。针对感染的不同部位和种属,采取有效治疗措施:预防性治疗、经验性治疗及目标性治疗,以挽救患者生命。

Diagnosis and Treatment Progress of Invasive Fungal Infections in Children

In recent years,invasive fungal infections(IFI) have been increasing in the children who have primary immunodeficiency disease or various secondary immunodeficiencies.IFI has a high fatality rate,especially in hospitalized critically ill children,so we should pay much attention to the risk factors of IFI,conduct related imaging test(such as chest CT scan) and do fast and accurate laboratory testing as soon as possible,including microscope examination,fungal culture,polymerase chain reaction and serum antige...