| 胰高血糖素样肽1研究进展 |
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| 引用本文： | 吴桂堂. 胰高血糖素样肽1研究进展[J]. 医学综述, 2011, 17(21): 3236-3240 |
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| 作者姓名： | 吴桂堂 |
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| 作者单位： | 广东医学院附属陈星海医院普外科,广东,中山,528415 |
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| 摘 要： | 胰高血糖素样肽1(GLP-1)主要由肠道内分泌L细胞分泌的一种肽,具有调控胰岛素分泌,刺激胰腺β细胞再生等生物学作用。近年来,GLP-1及其类似物开始应用于临床,特别是应用于治疗2型糖尿病。现对GLP-1的发现、结构、代谢与分泌进行介绍,并重点对其生物学作用、临床应用等方面予以综述。
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| 关 键 词： | 胰高血糖素样肽1 糖尿病 内分泌 |
The Progress of Glucagon-like Peptide-1 |
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| WU Gui-tang. The Progress of Glucagon-like Peptide-1[J]. Medical Recapitulate, 2011, 17(21): 3236-3240 |
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| Authors: | WU Gui-tang |
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| Affiliation: | WU Gui-tang1,QIN Wei2,WANG Hai-jiu2.(1.Department of General Surgery,CHEN Xing-hai Hospital Affiliated to Guangdong Medical College,Zhongshan 528415,China,2.Department of General Surgery,Affiliated Hospital of Qinhai University,Xining 810001,China) |
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| Abstract: | Glucagon-like peptide-1 is a peptide secreted mainly by intestinal endocrine L cells,with a variety of biological effects,such as regulation of insulin secretion and stimulation of the pancreatic β-cell regeneration,etc..In recent years,glucagon-like peptide-1 and its analogues began to be used clinically,especially to treat type 2 diabetes.Here is to make a review on the discovery,structure,metabolism and secretion,especially its biological applications and clinical application of glucagon-like peptide-1. |
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| Keywords: | Glucagon like peptide-1 Diabetes mellitus Endocrine |
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