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| 利培酮合并氯氮平治疗难治性精神分裂症对照研究 | |
| 引用本文： | 高亚娇,安红伟,靳红强. 利培酮合并氯氮平治疗难治性精神分裂症对照研究[J]. 医学综述, 2011, 17(21): 3342-3343 |
| 作者姓名： | 高亚娇 安红伟 靳红强 |
| 作者单位： | 河北省荣军医院十一病区,河北,保定,071000 |
| 摘 要： | 目的探讨利培酮联合氯氮平治疗难治性精神分裂症(TRS)的疗效及安全性。方法将63例TRS患者随机分为利培酮合并氯氮平组(治疗组)32例和利培酮组(对照组)31例,两组治疗后4、8、12周均以阳性与阴性症状量表(PANSS)评定疗效,治疗意外症状量表(TESS)评定不良反应。结果治疗组和对照组治疗TRS的疗效比较差异有统计学意义(P<0.05)。治疗后8周,两组PAN-SS总分均较治疗前下降,治疗组下降更明显。两组治疗12周后PANSS总分比较,治疗组明显低于对照组,差异有统计学意义(P<0.05)。结论利培酮联合氯氮平治疗TRS的疗效肯定,值得临床应用。 |
| 关 键 词： | 难治性精神分裂症 氯氮平 利培酮 |
Comparative Study on Risperidone Combined Clozapine and Risperidone in the Treatment of Refractory Schizophrenia |
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| GAO Ya-jiao,AN Hong-wei,JIN Hong-qiang. Comparative Study on Risperidone Combined Clozapine and Risperidone in the Treatment of Refractory Schizophrenia[J]. Medical Recapitulate, 2011, 17(21): 3342-3343 | |
| Authors: | GAO Ya-jiao AN Hong-wei JIN Hong-qiang |
| Affiliation: | GAO Ya-jiao,AN Hong-wei,JIN Hong-qiang.(The Eleventh Ward,Rongjun Hospital of Hebei Province,Baoding 071000,China) |
| Abstract: | Objective To compare the efficacy and safety of clozapine combined with risperidone in the treatment of refractory schizophrenia.Methods 63 cases were divided into two groups randomly,32 cases of treatment-refractory schizophrenia were treated with risperidone combined clozapine(the treatment group) and 31 cases were treated with risperidone(the control group).The clinical effect of patients were measured with positive and negative symptoms scale(PANSS),and side effects were assessed with treatment emergent... |
| Keywords: | Treatment-resistant schizophrenia Clozapine Risperidone |
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