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| 中国汉族人群GSTM1、GSTT1基因多态性与结直肠癌遗传易感性的Meta分析 | |
| 引用本文： | 闫书山,王平,徐栋花,孙倍成. 中国汉族人群GSTM1、GSTT1基因多态性与结直肠癌遗传易感性的Meta分析[J]. 医学综述, 2011, 17(19): 3014-3017 |
| 作者姓名： | 闫书山 王平 徐栋花 孙倍成 |
| 作者单位： | 1. 南京医科大学第一附属医院肝移植中心,南京,210000 2. 南京江北人民医院感染科,南京,210048 |
| 摘 要： | 目的探讨中国汉族人群中谷胱甘肽S-转移酶(GSTM1、GSTT1)基因多态性与结直肠癌遗传易感性的关系。方法采用Meta分析方法对国内外关于GSTM1、GSTT1基因多态性与结直肠癌遗传易感性的研究结果进行合并效应值估计和异质性相关因素的分析。共收集1994～2011年发表的相关文献13篇,累计病例1480例,对照3057例。结果在中国汉族人群中,GSTM1的空白基因型与结直肠癌的发生有关(ORGSTM1=1.38,95%CI 1.09～1.74,POR=0.007);GSTT1的空白基因型与结直肠癌的发生不存在关联关系(ORGSTT1=1.15,95%CI 1.00～1.32,POR=0.058);GSTT1和GSTM1的共同空白基因型与结直肠癌的发生存在关联关系,合并的OR值为1.40(95%CI 1.14～1.74;POR=0.002)。结论在中国汉族人群中,GSTM1的纯合缺失型是结直肠癌发生的危险因素,而GSTT1纯合缺失型则与结直肠癌的发生无关,但GSTM1与GSTT1的共同纯合缺失型可能协同促进了结直肠癌的发生。 |
| 关 键 词： | 谷胱甘肽S-转移酶 基因多态性 结直肠癌 Meta分析 |
A Meta-analysis of Null Genotypes of GSTM1 and GSTT1 Contributing to Colorectal Cancer Risk in Chinese Han Population |
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| YAN Shu-shan,WANG Ping,XU Dong-hua,SUN Bei-cheng. A Meta-analysis of Null Genotypes of GSTM1 and GSTT1 Contributing to Colorectal Cancer Risk in Chinese Han Population[J]. Medical Recapitulate, 2011, 17(19): 3014-3017 | |
| Authors: | YAN Shu-shan WANG Ping XU Dong-hua SUN Bei-cheng |
| Affiliation: | 1.Liver Transplantation Center of the First Affiliated Hospital,Nanjing Medical University,Nanjing 210000,China;2.Department of Infectious Diseases,People′s Hospital of Jiangbei,Jiangsu 210048,China) |
| Abstract: | Objective To explore the effects of GSTM1 and GSTT1 polymorphisms on CRC risk in Chinese Han population.Methods The Meta analysis was performed to estimate GSTM1 and GSTT1 deficiency associated with the risks of CRC at home and abroad,which involved evaluation of the pooling effect value and analysis of heterogeneity related characteristics.13 relevant records through a literature search from 1994 to 2011 were investigated,involving a total of 1480 CRC cases and 3057 controls.Results Analyses of total relev... |
| Keywords: | Glutathione S-transferase Gene polymorphism Colorectal cancer Meta-analysis |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |