2型糖尿病早期血管内皮功能改变的临床研究

目的：探讨2型糖尿病（T2DM）早期患者血管内皮功能的变化及影响因素。方法：选取45例新诊断无并发症的T2DM患者（T2DM组）,另设正常对照组38例（NC组）,比较两组的一般情况、血脂、糖代谢等生化指标和可溶性血管细胞黏附分子1（SVCAM-1）的差异。结果：①T2DM组SVCAM-1高于NC组[（47.51±13.84）mmol/L vs（27.99±11.66）mmol/L],差异有高度统计学意义（P〈0.01）。②相关分析显示,血清SVCAM-1与体重指数（BMI,r=0.432,P〈0.01）、舒张压（DBP,r=0.229,P〈0.05）、空腹血糖（FPG,r=0.409,P〈0.01）、三酰甘油（TG,r=0.226,P〈0.05）、总胆固醇（TC,r=0.237,P〈0.05）、低密度脂蛋白胆固醇（LDL-C,r=0.241,P〈0.05）呈显著正相关,与高密度脂蛋白胆固醇（HDL-C,r=-0.259,P〈0.01）呈显著负相关。结论：T2DM早期患者即存在血管内皮功能损伤。

Clinical study of vascular endothelial dysfunction in the early stage of type 2 diabetes mellitus

Objective： To investigate the alteration and influence factors of vascular endothelial dysfunction in patients at the early stage of type 2 diabetes mellitus.Methods： 45 T2DM patients without complications（T2DM group） and 38 normal subjects（normal control group,NC group） were recruited.General condition,lipid profiles,glycometabolism parameters,other serum biochemical parameters and SVCAM-1 of two groups were detected.Results： ①The SVCAM-1 levels in T2DM group were significantly higher than that of the NC group [（47.51±13.84）mmol/L vs（27.99±11.66）mmol/L,P0.01].②Positive correlations between the serum SVCAM-1 of the two groups level and BMI（r=0.432,P0.01）,DBP（r=0.229,P0.05）,FPG（r=0.409,P0.01）,TG（r=0.226,P0.05）,TC（r=0.237,P0.05） and LDL-C（r=0.241,P0.05） were showed by variable correlations.There was a negative correlation between the serum SVCAM-1 level and HDL-C（r=-0.259,P0.01）.Conclusion： There are endothelial dysfunction in the early stage of type 2 diabetes mellitus.