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| 三丁基锡对小鼠脏器组织总氧自由基清除能力的影响 | |
| 引用本文： | 叶怀庄,邢鸣鸾,钱江,俞智勇,徐立红. 三丁基锡对小鼠脏器组织总氧自由基清除能力的影响[J]. 环境与健康杂志, 2005, 22(3): 185-186 |
| 作者姓名： | 叶怀庄 邢鸣鸾 钱江 俞智勇 徐立红 |
| 作者单位： | 浙江大学医学院,浙江,杭州,310031;浙江大学医学院,浙江,杭州,310031;浙江大学医学院,浙江,杭州,310031;浙江大学医学院,浙江,杭州,310031;浙江大学医学院,浙江,杭州,310031 |
| 基金项目： | 国家自然科学基金资助项目(30270257) |
| 摘 要： | 目的探讨三丁基锡(TBT)对小鼠脏器组织的氧化应激的影响。方法雄性NIH小鼠24只,按体重随机分为8组,每组3只。以13%乙醇配制TBT,按照生理盐水、13%乙醇和10、20、40、80、160、320mg/kg体重的TBT灌胃给药,灌胃染毒24h,测定心、脑、肺、肝、肾组织匀浆液的总氧自由基清除能力(TOSC)。结果小鼠所有脏器组织的TOSC值均呈上升趋势,其中心、脑的变化显著,各剂量组与对照组比较均有统计学意义(P<0.05或P<0.01),TBT剂量与TOSC的相关系数均为正值。结论24hTBT染毒对小鼠的抗氧化能力影响呈正调作用。 |
| 关 键 词： | 三丁基锡 氧化应激 总氧自由基清除能力 |
| 文章编号： | 1001-5914(2005)03-0185-02 |
| 修稿时间： | 2004-05-13 |
Effect of Tri-n-butyltin on Total Oxyradical Scavenging Capacity in Mice Viscera Tissues |
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| YE Huai-zhuang,XING Ming-luan,QIAN Jiang,et al.. Effect of Tri-n-butyltin on Total Oxyradical Scavenging Capacity in Mice Viscera Tissues[J]. Journal of Environment and Health, 2005, 22(3): 185-186 | |
| Authors: | YE Huai-zhuang XING Ming-luan QIAN Jiang et al. |
| Affiliation: | YE Huai-zhuang,XING Ming-luan,QIAN Jiang,et al. Medical College,Zhejiang University,Hangzhou,Zhejiang 310031,China |
| Abstract: | Objective To investigate the oxidative stress caused by tri-n-butyltin (TBT) in mice. Methods 24 male NIH mice were chosen and the different doses of TBT were given per os for 24 h acute toxic test, meanwhile set the control group of 0.9% sodium chloride and 13% ethanol. The TOSC of heart, brain, lung, liver and kidney homogenates were detected by gas chromatography. Results After 24 h TBT exposure, TOSC of all viscera tissues was increased and this change was significant in the heart and brain, in every dose level, compared with the control (P<0.05 or P<0.01). The related coefficient was positive. Conclusion TBT up-regulates antioxidative capability of mice in 24 h acute toxic test. |
| Keywords: | Tri-n-butyltin (TBT) Oxidative stress Total oxyradical scavenging capacity |
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