胃食管反流病与幽门螺杆菌感染的关系探讨

目的探讨胃食管反流病与幽门螺杆菌感染之间的相关性。方法将经过电子胃镜确诊的GERD患者120例及对照组轻度慢性浅表性胃炎患者120例予血清幽门螺杆菌抗体检测和14C呼气试验法进行H.pylori检测,对比两组H.pylori感染情况;将90例反流性食管炎患者分为LA-A、B组及LA-C、D组,对比两组H.pylori感染情况;将120例GERD患者分为轻度症状组、中度症状组、重度症状组及极重度症状组,比较组间H.pylori感染情况。结果 GERD组H.pylori感染的阳性率(39.17%)低于对照组H.pylori感染的阳性率(62.50%),差异有统计学意义(P<0.05)。LA-A、B组H.pylori感染的阳性率(60.87%)高于LA-C、D组H.pylori感染的阳性率(29.55%),差异有统计学意义(P<0.05)。轻度症状组、中度症状组、重度症状组及极重度症状组H.pylori感染的阳性率分别是40.00%、41.67%、40.63%、31.82%。结论幽门螺杆菌感染是反流性食管炎的保护因素,幽门螺杆菌感染与GERD症状的发生无相关性。

Relationship between gastroesophageal reflux disease and infection of Helicobacter pylori

Objective To investigate the relationship between gastroesophageal reflux disease(GERD) and infection of helicobacter pylori(H.pylori).Methods 120 patients with GERD and 120 patients with low-grade chronic superficial gastritis diagnosed through endoscopy were checked by testing H.pylori antibody of serum and 14C-UBT.The H.pylori infection between experimental group and control group was compared.90 patients with reflux esophagitis(RE) were devided into LA-A,B group and LA-C,D group.The infection rate of H.pylori was compared.120 patients with GERD were divided into mild group,moderate group,severe group and the most severe group by the GERD symptom score.The infection rate of H.pylori was compared among the groups.Results The infection rate of H.pylori in GERD(39.17%) was remarkably lower than that in control group(62.50%),the difference was marked(P<0.05).The infection rate of H.pylori in LA-A,B group(60.87%) was higher than that in LA-C,D group(29.55%).The difference was marked(P<0.05).The infection rates of H.pylori in mild group,moderate group,severe group and the most severe group were 40.00%,41.67%,40.63% and 31.82%.Conclusion The H.pylori infection is a protective factor in the development of reflux esophagitis(RE).The H.pylori infection does not seem to play a major role in producing typial GERD symptoms.