烫伤消疤软膏对猪深Ⅱ度烧伤创面愈合影响的实验研究

目的观察烫伤消疤软膏对猪深Ⅱ度烧伤创面愈合影响。方法采用猪深Ⅱ度烧伤模型，创面外用烫伤消疤软膏，通过伤后不同时相点创面取材，检测烧伤创面羟脯氨酸（OHP）含量、创面细胞DNA含量和细胞周期变化、创面含水量、创面愈合率及组织病理形态学变化。结果创面外用烫伤消疤软膏后创面羟脯氨酸含量、创面细胞S期细胞百分比、创面愈合率均高于烧伤对照组，而创面含水量、创面细胞G

Experimental study on the effects of Tang Shang Xiao Ba burn ointment on deep partial thickness burn wound healing in pigs

Objective To observe the effects of TangShangXiaoBa burn ointment (TSXBBO) on deep partial thickness burn wound healing in pigs,and to investigate the possible mechanism of this traditional Chinese medicine in accelerating burn wound healing.Method A model of deep partial thickness burn wound in pigs was used.All wounds were divided into two groups,one side TSXBBO,and another control After topical application of TSXBBO to burn wound in pigs.the biopsies of burn wound were taken for measuring hydroxyproline contents,percentage of G0/G1－ phase and percentage of s－ phase in full skin cells of burn wound,water contents,rates of burn wound healing and pathological changes ingroup of TSXBBO and control at 1,3,5,7,10 and 14 day postburn.Result The hydroxyproline contents,the percentage of s－ phase in full skin cells of burn wound and the rates of burn wound healing were all higher,and the water contents and percentage of G0/G1－ phase were less in group TSXBBO than the control group.Conclusion It is suggested that topical application of TSXBBO to deep partial thickness burn wound in pigs may stimulate collagen synthesis,accelarate keratinocyte proliferation,reduce dropsy of burn wound and enhance wound healing.